摘要
目的观察模拟失重不同时期大鼠离体比目鱼肌肌梭电生理特性的改变。方法采用大鼠尾悬吊法建立模拟失重模型。雌性大鼠随机分为模拟失重 7d ,1 4d组以及对照组。采用电生理学方法 ,观察模拟失重不同时期离体比目鱼肌肌梭的自发放电及对动 -静式 (ramp and hold)牵拉反应特性的改变。结果模拟失重 7d组大鼠肌梭自发放电频率明显降低 ,对动 -静式牵拉反应性下降。 1 4d组变化更为显著。结论模拟失重可致肌梭的电生理特性发生明显的改变 。
Objective To study changes in electrophysiological characteristics of muscle spindles induced by simulated weightlessness in isolated rats soleus. Method Weightlessness was simulated by tail suspension in female rats. Using electro physiological technique,the spontaneous discharge of muscle spindle and its response to ramp and hold stretch were observed in isolated soleus of 7 d,14 d tail suspended and control rats. Result Soleus muscle spindles of rat manifest a sharp decrease in spontaneous discharge frequency and the response to ramp and hold stretch after 7 d tail suspension. More significant changes were observed in rats after 14 d tail suspension. Conclusion Simulated weightlessness could induce time related changes in electrophysiological characteristics of soleus muscle spindles in rat.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2004年第1期1-6,共6页
Space Medicine & Medical Engineering
基金
supportedbytheNationalNaturalScienceFoun dation( 3 0 0 780 83 0 )
关键词
失重模拟
尾吊
比目鱼肌
肌梭
电生理学
weightlessness simulation
tail suspension
soleus
muscle spindles
electrophysiology
