摘要
目的 观察全胃肠外营养对肝硬化大鼠肝功能及脂代谢的影响。方法 1 3只肝硬化大鼠随机分成 2组 ,肝硬化对照组 6只 ,肝硬化 TPN组 7只。观察大鼠生存情况 ,大鼠肝功能、血脂水平和肝脂含量的变化。结果 除 TPN组有一只大鼠因输液过快、肺水肿死亡外 ,其余大鼠均成活。与对照组比较 ,TPN组血清 TBIL、AST和 AL T无显著性差异 (P>0 .0 5 ) ,AL B明显降低 (P<0 .0 5 ) ,血清 TG水平明显升高 (P<0 .0 5 ) ,肝 TG、CHO含量明显升高 (P<0 .0 5 )。结论 硬化肝
Objective To investigate the effects of total parenteral nutrition (TPN) on liver function and lipid metabolism in the cirrhotic rats.Methods Thirteen cirrhotic rats were divided into two groups randomly: control group (n=6) and TPN group (n=7).Survival rate,Liver function,serum lipid and liver were observed.Result All animals survived but one rat died of pneumonedema in TPN group.Compared with control group,serum TBIL,AST and ALT had not significantly changes ( P >0.05),ALB was decreased significantly ( P <0.05),serum TG was increased significantly ( P >0.05),Liver TG and CHO were increased significantly ( P <0.05).Conclusion The changes of liver function and lipid metabolism must be observed when adminstration TPN on cirrhotic liver.
出处
《肝胆外科杂志》
2004年第1期66-67,共2页
Journal of Hepatobiliary Surgery
关键词
全胃肠外营养
肝硬化
肝功能
脂代谢
Total parenteral nutrition
Cirrhosis Liver function
Lipid metabolism
