摘要
目的 :研究啤酒花水提取液对去卵巢肥胖大鼠的影响。方法 :切除成年SD大鼠双侧卵巢后 ,口服啤酒花水提取液 ,观察对体重的影响。第 7周末取血测血清游离脂肪酸 (FFA)含量 ,总抗氧化能力 (T AOC) ,丙二醛(MDA)含量 ,雌激素 (E) ,雄激素 (T)和胰岛素 (Ins)水平。结果 :卵巢切除后大鼠体重增加。FFA含量升高 ,T AOC降低 ,MDA升高 ,E和T水平下降 ,Ins水平升高。口服啤酒花水提取液后 ,与去卵巢组大鼠比较 ,体重增加受到抑制 ,FFA含量降低 ,T AOC升高 ,MDA和Ins水平降低。结论 :啤酒花水提取液可抑制去卵巢大鼠的肥胖 ,此作用可能是啤酒花具有雌激素样活性 ,通过增加胰岛素敏感性 ,提高机体的总抗氧化能力实现的。
Objective: To investigate the effects of hops on obesity in ovariectomy rats. Mehtods: After ablating bilateral ovarian, adult Sprague-Dawley rats were drinken water extracts of hops and its effects on body weight were observed. On the seventh weekend, blood was collected to assay serum free fat acid(FFA), total anti-oxidative capacity(T-AOC), malondialdehyde(MDA), estrogen, testosterone and insulin. Results: Compared with SHAM group, rats in OVX group displayed the higher weight, serum FFA, MDA and levels of insulin, lower serum levels of estrogen and testosterone and T-AOC. After drinken water extracts of hops, compared with OVX group, rats in OVX+hops group had lower weight, serum FFA, MDA, levels of insulin and higher serum T-AOC. Conclusion: Hops could promote weight loss in OVX rats. Hops maybe have estrogen activity. It can increase sensibitity of insulin and elevate anti-oxidative capacity.
出处
《中药材》
CAS
CSCD
北大核心
2004年第2期105-107,共3页
Journal of Chinese Medicinal Materials
基金
甘肃省自然科学基金资助项目 (NO 2S0 2 1 A2 5 0 5 9 Y)
