摘要
目的 研究慢性阻塞性肺疾病(COPD)患者呼吸肌力及中枢驱动性与常规肺功能的关系。方法 对66例COPD患者进行最大吸气压、最大呼气压及口腔阻断压、常规肺功能测定及动脉血气分析。结果 COPD组最大吸气压及最大呼气压明显低于健康组,中枢驱动性明显高于健康组。COPD患者FRC/TLC％、RV％pred、FRC％pred及FEV_1与最大吸气压及中枢驱动性显著相关,其中FRC/TLC％与最大吸气压相关性最好(r=-0.581 P<0.001)。FEV_1和FRC/TLC％与最大呼气压无相关。动脉血氧分压及二氧化碳分压与最大吸气压相关,与最大呼气压及中枢驱动性无相关性。TLC％pred与最大吸气压、最大呼气压及中枢驱动性均无相关性。结论 COPD患者存在呼吸肌功能障碍,肺过度膨胀和气道阻塞是影响COPD患者吸气肌力的重要因素。
Purpose: In order to assess respiratory muscle strength and central inspiratory drive and their relationship to lung function tests in patients with chronic obstructive pulmonary disease (COPD). Methods: We measured in 66 patients with chronic obstructive pulmonary disease the maximum inspiratory and expiratory pressure (Pimax, Pemax, cm H2O% pred), Inspiratory pressure after 0.1 sec. at tidal breathing (P0.1), lung function and arterial gas analysis respectively. Results: COPD patients showed significantly lower Pimax and Pemax and higher P0.1 than normal subjects. The FRC/TLC%, RV% pred, FRC% pred and FEV1 were significantly correlated with Pimax and P0.1. Among them, Pimax was the most closely correlated with FRC/TLC% (r = - 0.581 P1, FRC/TLC% and Pemax. PaO2 and PaCO 2 were only correlated with Pimax. No relationship between PaO 2, PaCO2 and Pemax, P0.1 - TLC% pred was not correlated with Pimax, Pemax and P0.1. Conclusions: There is respiratory muscle strength dysfunction in COPD patients. Hyperinflation and airway obstruction predominantly affected inspiratory muscle strength in a group of COPD patients.
出处
《复旦学报（医学版）》
EI
CAS
CSCD
北大核心
2004年第1期63-65,68,共4页
Fudan University Journal of Medical Sciences
