摘要
大鼠ip前胡丙素(Pra-C 15 mg/kg,bid×3d)和硝苯啶(Nif 60μg/kg,bid×3d),使离体缺血再灌注工作心脏的收缩(AP,LVSP,+dP/dt_(max))舒张(-dP/dt_(max) LVEDP和T值)性能在35min时得到改善,尤以舒张性能改善明显,并能促进CO,CF,SV及HR恢复,改善心脏工作效率,减少CK释放和心肌线粒体钙含量,表明Pra-C和Nif对心肌缺血都有保护作用,Pra-C的效应与Nif相近。
The effects of praeruptorin C (Pra-C, 15 mg/kg, bid×3d, ip) on global myocar-dial ischemia and reperfusion were investigated in the isolated working rat hearts. The results at 35min after reperfusion showed that as compared with the values before ischemia, AP, LVSP, +dP/dt_(max), --dP/dt_(max),LVEDP and T were recovered up to 80±19%, 82±16%, 78±21%, 85±11%, 136±77% and 133±21%, respectively. The correspording parameters of Nifedipine (Nif,60 μg/kg, bid×3 d,ip) were 80±16%,97±30%,102±24%,106±32%,129±41% and 145±46%,respectively. The CF,SV and HR were recovered by 81±11%,104±20% and 78±7%when using Pra-C and 86±11%, 106±25% and 82±11%, respectively, when using Nif. Add-itionally ,in comparison of Pra-C and Nif with the ischemia group,the levels of creatine kinase releasedfrom cardiac cells decreased by 30% and 40%;while calcium accumulation in myocardial mitochondri-a were 41% and 46% ,respectively. The study suggests that the protective effects of Pra-Con myocar-dial cells in the isolated working rat heart during myocardial ischemia are similar to those Nif.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第10期729-733,共5页
Acta Pharmaceutica Sinica
基金
自然科学基金
关键词
前胡丙素
硝苯啶
血流动力学
Praeruptorin C
Nifedipine
Isolated working heart
Hemadynamics
Mitochondria
