摘要
用薄层扫描定量法测定盐酸甜菜碱在大鼠体内的血药浓度,所得药-时数据依3P87程序进行曲线拟合,计算药物动力学参数。大鼠一次iv盐酸甜菜碱400mg/kg后,药时曲线符合开放三室模型。AUC为14599.2(μg/ml)h;大鼠一次灌胃盐酸甜菜碱400mg/kg,药时曲线符合开放一室模型,AUC为10158.8(μg/ml)h。由此可以得出盐酸甜菜碱在大鼠体内的绝对生物利用度为69.58％。
The concentration of betaine hydrochloride in serum was studied in rats using quantitative TLC scanning technique. The serum drug concentration-time curve obtained after intravenous injection (400 mg/kg) of betaine hydrochloride to rats was shown to fit a three compartment open model, ALIC=14599.2 (μg/ml) h. The serum durg concentration-time curve obtained after oral administration (400mg/kg) of betaine hydrochloride to rats was shown to fit a one compartment open model, AUC=10158. 8(μg/ml)h. So the absolute bioavailability of betaine hydrochloride was 69.58％.
出处
《延边医学院学报》
CAS
1992年第2期111-114,共4页
Journal of Medical Science Yanbian University
