摘要
本实验采用水迷津法、步下法和步入法,用樟柳碱制备学习和记忆障碍的动物模型。结果表明,樟柳碱(10毫克/公斤)可使小鼠引起学习障碍,其表现为通过水迷津全程的时间延长,而且小鼠进入盲路的错误次数明显增多。樟柳碱(10毫克/公斤)可使小鼠引起记忆障碍,在樟柳碱的影响下,小鼠步下平台或步入暗箱的潜伏期明显缩短,并使它们的错误次数增多。本实验结果进一步表明,测定小鼠的记忆障碍,步入法似乎比步下法更为敏感。
Using anisodine to prepare animal models of learning and memory disorder
with water maze test, step clown test and step through test in mice was intro-
duced in this paper. The results showed, anisodine (10 mg/kg)could significantly
induce learning disorder in mice. Time through all pathways in the water maze
was prolonged and errors in passing the blind alleys obviously increased. Anis-
odine(10mg/kg)could significantly produce mempry dysfunction in mice: the
latencies of the step down test and step through test were significantly shorten-
ed, and errors of response in the step down test and step through test increased.
The results futher indicated that the step through test is more sensitive than the
step down test for testing memory dysfunction in mice.
出处
《心理学报》
CSSCI
CSCD
北大核心
1992年第1期73-79,共7页
Acta Psychologica Sinica
基金
中国科学院择优基金
关键词
樟柳碱
学习
记忆
水迷津法
anisodine
learning and memory
water maze test
step down test
step through test
animal model
