摘要
目的 比较糖尿病与冠心病患者血清可溶性细胞间粘附分子 1(sICAM 1)及可溶性E 选择素 (sE s)水平 ,以探讨粘附分子在糖尿病大血管病变发生、发展中的作用。方法 采用酶联免疫吸附法 (ELISA)检测 61例 2型糖尿病 (糖尿病组 )和 5 8例冠心病 (冠心病组 )患者及 42名正常组 (对照组 )的血清sICAM 1、sE s水平 ,酶法检测血糖、血脂等。结果 糖尿病组与冠心病组sICAM 1及sE s水平均高于对照组 (P <0 .0 1) ,糖尿病组sICAM 1水平高于冠心病组 ,sICAM 1水平与总胆固醇、低密度脂蛋白胆固醇呈正相关。结论 ICAM 1及E s可能参与了糖尿病大血管病变及冠心病的发病机制 ,糖尿病具有高度的心血管疾病风险。血脂是影响sICAM 1水平的因素之一。
Objective To measure and compare the serum sICAM-1 and sE-selectin in patients with diabetes mellitus and patients with coronary heart disease.Methods Determine the level of sICAM-1 and sE-s by ELISA in three groups(DM group,CHD group and normal control group ),measure the level of serum lipid and glucose.Results The level of sICAM-1 and sE-s in both group DM and group CHD were significantly higher than those in group NC,the serum sICAM-1 in group DM was significantly higher than that in group CHD(386.3±59.7vs344.1±63.2 P<0.05),the level of sICAM-1 was positively related to that of serum LDL and TC.Conclusion sICAM-1 and sE-s may involve in the pathogenesis of diabetic vascular complication and CHD,DM patients run high risks of cardiac vascular disease.Serum lipid have effect on the level of ICAM-1.
出处
《临床内科杂志》
CAS
北大核心
2004年第2期117-119,共3页
Journal of Clinical Internal Medicine
关键词
糖尿病
冠心病
细胞粘附分子
E.选择素
Diabetes mellitus
Coronary heart disease
Intercellular adhension molecule
E-selectin
