摘要
目的 探讨狼疮性肾炎 (LN)患者血浆及肾组织白细胞介素 13 (IL 13 )的表达及其临床意义。方法 采用ELISA法检测血浆IL 13水平 ,采用免疫组化ABC法检测肾组织IL 13的表达。结果 LN患者血浆IL 13水平、肾小球及肾小管间质区IL 13表达较对照组和非LN肾脏病对照组增高 ,以Ⅳ型LN患者肾小球区IL 13表达最高 ,而不同病理类型的LN肾小管间质区IL 13表达无显著性差异。LN患者血浆及肾小管间质区IL 13表达与Ccr和血清C3 呈负相关 ,与肾小管间质病变活动指数和肾小球病变活动指数呈正相关。结论 IL 13参与LN的分子病理机制 ,血浆及肾组织IL
Objective To elucidate the expression of interleukin13(IL-13)in plasma and renal tissues and its clinical significance in human lupus nephritis(LN).Methods Plasma level of IL-13 was examined by ELISA.The expression of IL-13 in renal tissue was examined by immunohistochemistry ABC technology.Results Plasma level of IL-13 in patients with LN was significantly higher than that in control groups.IL-13 in the glomerulus and tubulointerstitium in patients with LN was higher than that in control groups and was the highest in the patients with Ⅳ type LN.The expression of IL-13 in plasma and tubulointerstitium was correlated negatively with Ccr and serum C3,and positively with glomerulus active index and interstitial active index.Conclusion IL-13 may play multi-effective biologic roles in the molecular pathogenesis of LN,the expression of IL-13 in plasma and tubulointerstitium may be useful to judge the active degree of LN.
出处
《临床内科杂志》
CAS
北大核心
2004年第2期102-104,共3页
Journal of Clinical Internal Medicine
基金
广东省自然科学基金项目 (项目编号 0 0 1 534)
广东省卫生厅项目 (项目编号B2 0 0 1 0 81 )资助
