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循环DNA、循环肿瘤细胞端粒酶与肿瘤早期诊断 被引量:3

Circulating DNA,Telomerase of Circulating Tumor Cells and Early Diagnosis of Tumors
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摘要 肿瘤患者循环DNA水平的增高、肿瘤特征性基因改变及循环肿瘤细胞端粒酶活性的表达,不仅可出现在肿瘤的晚期,也可发生在肿瘤的早期阶段。循环DNA和肿瘤细胞端粒酶的联合检测,对于肿瘤早期诊断有重要意义。 The increase of circulating DNA levels, the mutations of tumor characteristic genes and the telomerase expression of circulating tumor cells can be detected not only in advanced stage but also in early stage of tumors. The combinational detection of circulating DNA and telomerase of circulating tumor cells is useful for the early diagnosis of tumors.
作者 张忠 袁媛
出处 《癌症》 SCIE CAS CSCD 北大核心 2004年第2期227-229,共3页 Chinese Journal of Cancer
关键词 肿瘤 早期诊断 循环DNA 循环肿瘤细胞端粒酶 Circulating DNA Circulating tumor cells Telomerase Tumor Diagnosis
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  • 1Mandel P,Metais P.Les acides nucléiques du plasma sanguin chez l'homme[J].C R Seances Soc Biol Fil,1948,142(3-4):241-243.
  • 2Leon S A,Shapino B,Skaaroff D M,et a1.Free DNA in the serum of cancer patients and the effect of therapy[J].Cancer Res,1977,37(7):646-650.
  • 3Chang H W,Lee S M,Goodman S N,et al.Assessment of plasma DNA levels,allelic imbalance,and CA 125 as diagnostic tests for cancer[J].J Natl Cancer Inst,2002,94(22):1697-1703.
  • 4Herrera L J,Raja S,Gooding W E,et al.Quantitative analysis of circulating plasma DNA as a tumor marker in thoracic malignancies[J].Clin Chem,2005,51(1):113-118.
  • 5Roth C,Kasimir-Bauer S,Pantel K,et al.Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer[J].Mol Oncol,2011,5(3):281-291.
  • 6Heitzer E,Auer M,Hoffmann E M,et al.Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer[J].Int J Cancer,2013,133(2):346-356.
  • 7De Mattos-Arruda L,Weigelt B,Cortes J,et al.Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA:a proof-of-principle[J].Ann Oncol,2014,25(9):1729-1735.
  • 8Alix-Panabières C,Schwarzenbach H,Pantel K.Circulating tum or cells and circulating tumor DNA[J].Annual Rev Med,2012,63:199-215.
  • 9Chang H W,Tsui K H,Shen L C,et al.Urinary cellfree DNA as a potential tumor marker for bladder cancer[J].Int J Biol Markers,2007,22(4):287-294.
  • 10Goebel G,Zitt M,Zitt M,et a1.Circulating nucleic acids in plasma or serum as prognostic and predictive markers in patients with solid neoplasias[J].Dis Markers,2005,21(3):105-120.

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