摘要
AIM: To investigate the possible roles of p53 and C-mycgenes in the primary hepatocellular carcinogenesis and therelationship between the liver hyperplastic nodule(LHN) andhepatocellular carcinoma(HCC).METHODS: The expression of p53 and C-myc genes wasdetected immunohist-ochemically in 73 and 60 cases of HCCand pericarcinomatous tissues, respectively .RESULTS: The positive expression of p53 in HCC wassignificantly higher than that in pericarcinomatous tissues(P＜0.05). In pericarcinomatous tissues, the p53 expressionwas observed only in LHN, but not in liver cirrhosis (LC) andnormal liver tissues. The positive expression rate of C-mycin HCC or LHN was significantly higher than that in LC ornormal liver tissues (P＜0.05 and P＜0.01), however, nosignificant difference was found between HCC and LHN(P＞0.05). The positive expression rate of p53 and C-myc inHCC was correlated with the histological differentiation, thatin the poorly differentiated was significantly higher than thatin well differentiated samples (P＜0.05).CONCLUSION: The overexpression of p53 and C-myc genesmight play a role in the carcinogenesis of HCC; And LHNseems a preneoplastic lesion related to hepatocarcinogenesis;No evidence supports that LC contribute directly to thehepatocarcinogenesis.
AIM:To investigate the possible roles of p53 and C-myc genes in the primary hepatocellular carcinogenesis and the relationship between the liver hyperplastic nodule(LHN)and hepatocellular carcinoma(HCC). METHODS:The expression of p53 and C-myc genes was detected immunohist-ochemically in 73 and 60 cases of HCC and pericarcinomatous tissues,respectively. RESULTS:The positive expression of p53 in HCC was significantly higher than that in pericarcinomatous tissues (P<0.05).In pericarcinomatous tissues,the p53 expression was observed only in LHN,but not in liver cirrhosis(LC)and normal liver tissues.The positive expression rate of C-myc in HCC or LHN was significantly higher than that in LC or normal liver tissues(P<0.05 and P<0.01),however,no significant difference was found between HCC and LHN (P>0.05).The positive expression rate of p53 and C-myc in HCC was correlated with the histological differentiation,that in the poorly differentiated was significantly higher than that in well differentiated samples(P<0.05). CONCLUSION:The overexpression of p53 and C-myc genes might play a role in the carcinogenesis of HCC;And LHN seems a preneoplastic lesion related to hepatocarcinogenesis; No evidence supports that LC contribute directly to the hepatocarcinogenesis.
基金
the scientific research fundation of Shandong Provincial Education Committee(J94,K26)
