摘要
细胞因子IL 1、IL 6、PAI 1、TNF、内皮素、选择素、组织因子及血小板活化因子 (PAF)等 ,均参与弥散性血管内凝血 (DIC)的病理过程。DIC的诊断应包含 :①前凝血物系统激活 ;②纤溶系统激活 ;③抑制物的消耗 ;④细胞因子的释放 ;⑤细胞的激活 ;⑥终末器官的损害。以上六个基本病理过程中①、②、③、⑥及其相应的实验参数异常必须具备。DIC治疗以病因治疗为根本 ,抗凝治疗和血液成分补充为治疗之基石。抑制蛋白分解酶、凝血酶、因子Χa、PAF的药物及活化的蛋白C、重组凝血酶调节蛋白等加强抗凝或 (和 )纤溶的药物是研究开拓中的有效药物 ,正引起临床的关注。
Interleukin (IL) 1,IL 6,plasminogen activator inhibitors 1(PAI 1),tumor necrosis factor(TNF),endothelin, silectin E, tissue factor(TF) and platelet activating factor(PAF)etc. participated in pathological processes of disseminated intravascular coagulation(DIC).Diagnosis of DIC should possess:①procoagulant system activation,②fibrinolytic system activation,③inhibitor consumption,④cytokine release,⑤cellular activation, and ⑥resultant end organ damage. For an objective diagnosis of DIC,①,②,③,⑥must be present and documented by appropriate laboratory parameters. To remove the triggering process or the underlying disease during the treatment of DIC was fundamental. Anticoagulation therapy and component therapy were the foundation stone. The inhibitor of proteinase, thrombin, factor Χa,and drugs of enhancing anticoagulation or (and) fibrinolytic, ie, platelet activating factor (PAF),activating protein C (APC),recombinant thrombomodulin (rTM) etc. are effective drugs in studying and developing.
出处
《医学研究生学报》
CAS
2003年第10期783-786,共4页
Journal of Medical Postgraduates
关键词
弥散性血管内凝血
诊断
治疗
Disseminated intravascular coagulation
Diagnosis
Treatment
