摘要
探讨某些黄烷酮、黄酮和查耳酮的合成方法,提出以丙二及相应的芳香醛、酚为原料,通过Knoevenagel缩合和Hoesch单酰基化反应,同时水解、脱羧、关环而直接得到黄烷酮类化合物,以α-卤代-2-羟基苯乙酮类化合物与芳香醛在5～10％NaOH乙醇水溶液中室温下反应,直接合成黄酮类化合物,省去以往通过查耳酮、黄烷酮的卤化、水解或脱卤化氢的繁琐步骤,提供了合成黄酮的简便方法,同时探讨了查耳酮的合成和关环。
A new route to prepare some flavanones was reported. The flavanones were obtained by knoevengel condensation of malononitrile with aromatic aldehydes to phenylmethylene propanedinitriles (1), the resulting then by Hoesch acylation with phloroglucinol, following by hydrolysis , decarboxylation and ring closure. A facial method for the preparation of flavones was described. Namely, the aldol condensation of α-chioro-2-hydroxy acetophenones with aromatic aldehydes in aqueous alcoholic solution containing 5-10% NaOH at room temperature was shown to give flavone directly in high yield.
出处
《厦门大学学报（自然科学版）》
CAS
CSCD
北大核心
1992年第6期651-656,共6页
Journal of Xiamen University：Natural Science
关键词
黄酮
黄烷酮
缩合
黄酮类化合物
Flavone, Flavanonc, Chalkon, Condensation, Synthesis
