摘要
合成了7对B环有不同取代基的7-羟基黄烷酮和7-羟基黄酮。比较了它们对离体豚鼠心脏冠脉流量、心肌收缩力和心率的影响。发现2,3-位双键存在时抑制心肌收缩的作用较为明显。
Seven pairs of B-ring substituted 7-hydroxyflavanones and7-hydroxyflavones were synthesized and tested on isolated guinea pig hearts(Langendorff's method).It was found that flavones had marked inhibition effecton the myocardial contractility.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1989年第9期392-398,共7页
Chinese Journal of Pharmaceuticals
基金
国家自然科学基金
关键词
黄烷酮
黄酮
合成
生物活性
flavanone, flavone,coronary flow,heart rate,myocardial contractility
