摘要
本文研究了大豆异黄酮纯级分(SI-Ⅱ)的降血糖作用。结果表明:SI-Ⅱ能显著(p<0.01)降低四氧嘧啶糖尿病小鼠的血糖水平,显著(p<0.01)提高其血清胰岛素浓度,缓解糖尿病症状;抑制胰岛细胞Fas蛋白表达,促进胰岛β细胞的恢复;而且能增加糖尿病小鼠的免疫器官重量。提示大豆异黄酮具有降血糖作用,其作用机制可能是通过抑制胰岛细胞凋亡、提高免疫功能等途径促进胰岛β细胞功能恢复。
This paper was performed on hyperglycemia Lowering effect of a purified fraction of Soybean Isoflavone(SI-Ⅱ)in diabetic mice. The results showed that after intake of SI-Ⅱ for 12d at adose level of 50～100 mg/(kg·d) continuously, thehyperglycemic mice induced by Alloxan lowered the fasting blood sugar level significantly (p<0.01) as compared with the controls.SI-Ⅱ could enhance insulin concentration of alloxan-inducing diabetes mice significantly (p<0.01) and improve the cardinal symptomsof diabetes mice, such as water-intake, food-intake, protein expression and body weight. SI -Ⅱ could restore the injury of alloxan-inducedpancreas islet observed by histopathological section. The immunohistochemical result indicated that SI -Ⅱ was capable to inhibit theexpression of Fas by pancreas islet. The results also showed that SI-Ⅱ could increase the immune organ weight in alloxan-inducingdiabetes mice remarkably (p<0.01). Meanwhile, SI-Ⅱ could not affect the blood sugar level of normal mice. The studies implied thatrecovering the alloxan-induced β cell damage via the way of inhibiting the apoptosis of the beta cells of pancreas islet and enhancingimmune function might be of the important hyperglycemia lowering mechanism of SI.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2004年第1期166-170,共5页
Food Science
