摘要
目的:研究强直性脊柱炎(ankylosingspondylitis,AS)患者骨矿物质密度(bonemineraldensity,BMD)的变化,并探讨强直性脊柱炎患者发生骨质疏松的机理。方法:采用定量超声骨密度仪测定210例AS患者跟骨的骨密度,其中男165例,女45例,并与性别、年龄匹配的健康人作对照,分析AS的骨质疏松发生率。结果:AS患者早期即有较高的骨质疏松发病率,AS组骨密度(患者骨密度观测定和年轻人骨密度峰值的比较,t-Score)均显著低于对照组(男:-2.32±1.19和1.26±0.89,女:-1.01±1.18和1.45±0.36;t=29.8,13.7,P<0.05);AS组骨质疏松发生率(男47.9%,女2%)与对照组(男7.3%,女4%)比较差异有显著性意义(χ2=8.77,0.35,P<0.05)。HLA-B27(+)与HLA-B27(-)患者骨密度(-2.26±1.15和-2.56±0.70)比较无显著性差异(t=1.47,P>0.05)。结论:骨质疏松是AS患者的常见并发症,疾病早期即有骨质疏松发生,超声骨密度可敏感检测AS继发骨质疏松,提示对AS患者早期既应注意骨质疏松的防治。
AIM:To study the changes of the bone mineral density(BMD) in ankylosing spond ylitis(AS) patients and explore the mechanism of osteoprosis(OP) in patients wit h AS. METHODS:The BMD of calcaneum bones in 210 AS patients(165 males and 45 female s) were measured by quantitative ultrasound,and were contrasted with the normals .The incidence of OP in AS was also analyzed. RESULTS:The high incidence rate of OP was found even in the early stage of AS.The BMD of AS patients(comparison of BMD determining result and BMD peak of youth,t- score) was significantly lower than that of the control group( male:-2.32± 1.19,1.26± 0.89, female:-1.01± 1.18,1.45± 0.36; t=29.8, 13.7; P< 0.05) .There was significant di fference in the incidence rate of OP between AS patients(male:47.9% ,female:2% ) and control group(male:7.3% ,female: 4% )( ÷ 2=8.77, 0.35, P< 0.05) . However,no difference was found in the incidence rate of OP between the HLA- B2 7(+ ) patients and HLA- B27(-) patients. CONCLUSION:OP is a common complication in AS patients and can be found even i n the early stage of disease,ultrasound BMD can detect AS secondary osteoporosis sensitively.Therefore, the prevention of OP should be emphasised in AS patients .
出处
《中国临床康复》
CSCD
2004年第3期502-503,共2页
Chinese Journal of Clinical Rehabilitation
