摘要
目的 观察新城疫病毒 (NDV)对晚期癌症的治疗效果。方法 NDV注入经 37℃孵育 10天的SPF种蛋尿囊液中扩增NDV病毒 ,培养 72小时后收集含有病毒的尿囊液 ,经超速离心等方法提纯 ;以血凝试验等方法测定其滴度和活性。采用NDV治疗 77例晚期癌症患者 ,比较治疗前后淋巴细胞亚群变化。结果 应用NDV治疗 77例晚期癌症患者 ,总有效率 19例 (2 4 .6 8% ) ;完全缓解 2例 (2 .6 0 % ) ,部分缓解 17例 (2 2 .0 8% ) ,稳定 4 5例 (5 8.4 5 % ) ,进展 13例 (16 .88% )。患者经NDV治疗后 ,NK细胞数量增加。结论 NDV治疗晚期癌症有一定的疗效 ,值得进一步研究。
Objective To observe the effect of Newcastle disease virus(NDV) on advanced cancer. Methods The NDV was injected into allantoic cavity of SPF hen's eggs that were hatched for 10 days in 37 ℃ for virus to replicate and expand. The allantoic liquid containing NDV was collected after vaccination for 72 hours and purified by the ways of superspeed centrifugatization. The activity of NDV was detected by the agglutination.The lymphocytes in peripheral blood were detected in 77 advanced cancer patients treated with NDV. Results The total response rate(CR+PR) in 77 patients was 19(24.68%),with 2(2.60%) complete response(CR),17(22.08%) partial response(PR),stable in 45(58.45%)NDV and progressive in 13(16.88%).The number of NK lymphocytes increased after treatment by NDV. Conclusion Newcastle disease virus is effective in treating advanced cancers,which is worth to further study.
出处
《中国综合临床》
北大核心
2004年第1期37-38,共2页
Clinical Medicine of China
基金
辽宁省重点科研经费资助项目 (8952 1 5)
关键词
新城疫病毒
恶性肿瘤
晚期
副作用
Newcastle disease virus
Advanced benign cancer
Side effect
