摘要
目的:探讨卵巢肿瘤组织中VEGF表达及其受体与临床病理的关系。方法:对54例卵巢恶性肿瘤、14例卵巢良性肿瘤和16例正常卵巢组织采用免疫组织化学方法测定其VEGF及受体蛋白表达,并分析与临床病理的关系。结果:1)恶性肿瘤组织中VEGF及其受体蛋白表达阳性率明显高于良性肿瘤和正常卵巢组织,均有显著性差异(P<0.01)。2)恶性肿瘤内的VEGF表达阳性率与临床分期无明显相关(P>0.05)。但VEGF受体蛋白表达阳性率在晚期患者组织中明显高于早期患者(P<0.05)。3)VEGF受体表达阳性与其患者的腹水量、大网膜转移和盆腹腔淋巴结转移阳性呈正相关(P<0.05)。4)恶性肿瘤组织中VEGF及其受体蛋白共表达阳性者的平均总生存期明显低于不表达者。Kaplan-Meier生存曲线分析显示,二者累积生存率有显著性差异(P<0.05)。结论:恶性肿瘤组织中的VEGF及其受体蛋白阳性表达明显增高,其受体表达与患者的临床分期、腹水量、大网膜和盆腹腔淋巴结转移相关,VEGF及其受体蛋白共表达为卵巢癌患者的不良预后。
Objective:To explore the relationship between vascular endothelial growth fac-tor(VEGF)as well as receptors of ovarian neoplasm and it’s clinic-pathology.Methods :Strepta-vidin-Peroxidase immunohistochemistry method was used to determine the expression of VEGF and VEGF-receptors in54cases of ovarian malignant 、14cases of ovarian benign neoplasm and16cases of normal control.Results:(1)The expression of VEGF and receptors in ovarian malig nant was higher than that in ovarian benign neoplasm and normal control(P<0.01).(2)The expression of VEGF-receptor in patients with late stage was higher than that in early stage(P<0.05).(3)VEGF-receptors was observed more frequently in patients with large amount of ascitic volume 、o-mentum and lymph node metastasis(P<0.05).(4)The average survival in The expression of VEGF and receptors positive patients was less than that in the expression of VEGF and receptors nega-tive,Kaplan-Meier survival curve showed that there was significantly difference between the ex-pression of VEGF and receptors positive and negative patients.Conclusion:The expression of VEGF and receptors in ovarian malignant was higher.VEGF-receptor was related with large amount of ascitic volume of patient with ovarian carcinomas.The co-expression of VEGF and its receptor had a poorly overall survive in ovarian cancer patients.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2003年第7期466-469,共4页
Chinese Journal of Clinical Oncology
基金
广西壮族自治区自然科学基金资助(桂科回009009)
