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NF-κB的活化与神经细胞凋亡 被引量：3

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摘要 NF κB是机体在受到各种应激性刺激后参与调控一系列基因转录的关键性的核转录因子 ,在机体的器官发育、免疫反应、感染和组织损伤中发挥着重要作用 ,尤其近年来NF κB在调控中枢神经系统神经细胞凋亡中的作用日益受到重视。
作者 刘玲 杨于嘉
机构地区 贵阳市妇幼保健院新生儿科 中南大学湘雅医院儿科
出处 《国外医学（生理病理科学与临床分册）》 2003年第6期621-623,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 NF-ΚB 脑缺血缺氧 神经细胞凋亡
分类号 R363 [医药卫生—病理学]
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参考文献21

  • 1Domanska-Janik K, Bronisz-Kowalczyk A,Zajac H,et al. Interrelations between nuclear-factor kappa B activation, glial response and neuronal apoptosis in gerbil hippocampus after ischemia[ J]. Acta Neurobiol Exp (Warsz) , 2001,61 (1):45-51.
  • 2Ifickenbottom SL,Grotta JC, Strong R, et al. Nuclear factor-kappaB and cell death after experimental intracerebral hemorrhage in rats[ J ]. Stroke, 1999,30 ( 11 ) :2472-2477.
  • 3Aronowski J, Strong R, Kang HS, et al. Selective up-regulation of IkappaB-alpha in ischemic penumbra following focal cerebral ischemia[ J]. Neuroreport, 2000,11 (7) :1529-1533.
  • 4Ravati A, Atlemeyer B, Becker A,et al. Preconditioning-induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor-kappaB [ J ]. J Neurochem, 2001,78 (4) :909-919.
  • 5Nonaka M, Chen XH, Pierce JE,et al. Prolonged activation of NFkappaB following traumatic brain injury in rats[ J]. J Neurotrauma,1999,16( 11 ): 1023-1034.
  • 6Hill WD,Hess DC, Carroll JE,et al. The NF-kappaB inhibitor diethyldithiocarbamate (DDTC) increases brain cell death in a transient middle cerebral artery occlusion model of ischemia [ J ]. Brain Res Bull, 2001,55 ( 3 ) :375-386.
  • 7Taglialatela C, Kaufnann JA, Trevino A, et al. Central nervous system DNA fragmentation induced by the inhibition of nuclear factor kappa B [ J ]. Neuroreport, 1998,9 ( 3 ) :489-493.
  • 8Matsushita H,Morishita R,Nata T,et al. Hypoxia-induccd endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl2 suppression:in vivo evidence of the importance of NF-kappaB in endothelial cell regulation[J]. Circ Res,2000,86(9) :974-981.
  • 9Clemens JA, Stephenson DT, Yin T,et al. Drug-induced neuroprotection from global ischemia is associated with prevention of persistent but not transient activation of nuclear factor-kappaB in rats[J].Stroke, 1998,29 ( 3 ) :677-682.
  • 10Schneider A, Martin-Villalba A, Weih F, et al. NF-kappaB is activated and promotes cell death in focal cerebral ischemi a [ J]. Nat Med, 1999,5(5) :554-559.

同被引文献21

  • 1陶陆阳,丁梅,陈溪萍,卞士中,官大威.大鼠脑挫伤后NF-κB表达的分子生物学研究[J].法医学杂志,2004,20(2):73-76. 被引量：13
  • 2钱祝银,刘训良,苗毅.反义核调节因子-κBp65基因对重症急性胰腺炎肺组织的保护作用[J].江苏医药,2005,31(6):436-438. 被引量：2
  • 3姚轶群,崔承志,徐英辉,罗其中.NF-κB在胶质瘤细胞凋亡中的作用[J].国际神经病学神经外科学杂志,2007,34(1):48-51. 被引量：2
  • 4张俊志,郑少江,赵洪洋.NF-κB与Survivin基因在脑胶质瘤中的表达[J].中国临床神经外科杂志,2007,12(3):165-168. 被引量：4
  • 5Rongione AJ,Kusske AM,Ashley SW,et al.Interleukin 10reduces the severity of acute pancreatitis in rats.Gastroenterology,1997,112:960-967.
  • 6Menza MA,Murraay GB.Pancreatic encephalopathy.Biol Psychiatry,1989,25:781-784.
  • 7O'Neill LA,Kaltschmidt C.NF-kappa B:a crucial transcription factor for glial and neuronal cell function.Trends Neurosci,1997,20:252-258.
  • 8Zhu Y,Culmsee C,Klumpp S,et al.Neuroprotection by transforming growth factor-beta 1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen activated protein kinase-extracellular signal tegulated kinase 1,2 signaling pathways.Neuroscience,2004,123:897 -906.
  • 9Lankisch PG,Ihse I.Bili-induced acute experimental pancreatitis[J].Scand J Gastroenterol,1987,22(3):257-260.
  • 10Zhu Y,Culmsee C,Klumpp S,et al.Neuroprotection by transforming growth factor-betal involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinasel,2 signaling pathways[J].Neuroscience,2004,123(4):897-906.

引证文献3

二级引证文献8

国外医学（生理病理科学与临床分册）
2003年 第6期

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