摘要
目的 研究血管生成素 (Ang)家族中Ang 1、Ang 2蛋白在人脑胶质瘤组织中的表达水平 ,探讨其与脑胶质瘤临床病理特征的关系。方法 采用免疫组化方法 ,检测 42例人脑胶质瘤组织中Ang 1和Ang 2蛋白的表达。 结果 Ang 1、Ang 2蛋白在胶质瘤细胞和血管内皮细胞中均有表达。Ang 1的表达水平与患者临床病理特征无明显相关性 (P >0 .0 5 )。Ang 2蛋白表达水平与胶质瘤的临床病理分级、瘤周脑水肿程度显著相关 (P <0 .0 1) ,而与患者性别、年龄、肿瘤大小无关。结论 Ang 2过表达与临床病理分级和瘤周脑水肿密切相关 。
Objective To study the expression of angiopoietins in human brain gliomas and the relationship between the expression of angiopoietins and clinical pathologic parameters.Methods The expressions of Ang-1 and Ang-2 protein in samples from 42 human gliomas were detected by immunohistochemistry.Results The expression of Ang-1 and Ang-2 was found in both glioma cells and endothelium.The expression rates of Ang-1 and Ang-2 were 9.59%±3.48%和16.14%±9.81%.Ang-1 was not related with the patient′s sex,age,histological grade,brain edema grade,size of tumor(P>0.05).Ang-2 was significantly related with histopathological grade and brain edema grade(P<0.01),but was not related with sex,age and the size of tumors.Conclusion The results suggest that overexpression of Ang-2 is associated with histopathological grade and brain edema of tumors and might beused as one of the markers of malignant progression and poor prognosis in patients with glioma.
出处
《实用癌症杂志》
2003年第6期568-570,共3页
The Practical Journal of Cancer
