摘要
目的:研究血管生成素-2(Ang-2)及基质金属蛋白酶-7(MMP-7)蛋白在人大肠癌组织中的表达及其与大肠癌临床病理特征的关系．方法:应用免疫组化法检测40例大肠癌及其癌旁正常组织中Ang-2及MMP-7蛋白表达水平．结果:大肠癌组织中Ang-2蛋白表达阳性率为77．5％(31/40),明显高于癌旁正常组织 40％(16/40)(P=0．001);Ang-2表达水平与患者性别、年龄及癌组织的部位、大小、分化程度、淋巴结转移无关(P>0．05);与浸润深度, 远处转移及Dukes’分期相关(分别为P=0．007, P=0．023,P=0．008);大肠癌组织RMMP-7蛋白表达阳性率为85％(34/40),明显高于癌旁正常组织35％(14/40)(P=0．000)．MMP-7蛋白表达阳性率与Ang-2的表达相关(P=0．016)．结论:Ang-2蛋白可能通过促进MMP-7的表达从而促进了大肠癌的生长及转移．
AIM： To investigate the expression of angiopoietin-2 （Ang-2） and matrix metalloproteinase-7 （MMP-7） protein in human colorectal carcinoma, and to explore the relationship between the two proteins and clinical parameters. METHODS： Immunohistochemical technique was used to detect the expression of Ang-2 and MMP-7 protein in 40 colorectal carcinoma and their adjacent normal tissues. RESULTS： The positive rates of Ang-2 and MMP-7 were significantly higher in colorectal carcinoma than those in normal tissues （77.5% vs 40%, P = 0.001; 85% vs 35%, P = 0.000）. The level of Ang,2 expression had no marked correlations with the sex and age of patients as well as the site, size, lymph node metastasis or histological differentiation of colorectal carcinoma （all P〉 0.05）, but it was notably correlated with the invasion depth （P = 0.007）, distal metastasis （P = 0.023） and Dukes＇ staging （P = 0.008）. The expression of Ang-2 and MMP-7 were also significantly correlated （P = 0.016）. CONCLUSION： High expression of Ang-2 protein may play an important role in the progression and metastasis of colorectal carcinoma through up-regulation of MMP-7 expression.
出处
《世界华人消化杂志》
CAS
北大核心
2006年第4期434-437,共4页
World Chinese Journal of Digestology
