摘要
目的 探讨EBV与HCC的关系及与其它病毒有无协同作用。方法 采用PCR及免疫组化方法检测石蜡包埋HCC标本中EBV。结果 PCR测EBVDNA(BamH1W和 /或LMP1)阳性率为 2 8 2 %。免疫组化测EBVLMP1多定位于肿瘤细胞中。结论 EBV在HCC组织中有较高的检出率 ,可能在HCC的发生中起一定作用。
Objective To study the relationship between Epstein-Barr virus(EBV) and Hapatocellular carcinoma (HCC). Methods Polymerase chain reaction (PCR) and immunohistochemical staining were applied to detect EBV in paraffin tissue sections from 78 HCC patients. Results EBV DNA was detected in 22 patients (28 2%) by PCR. Immunohistochemical staining of EBV LMP1 revealed that the positive signals were mainly localized in the tumor cells. Conclusions These observations suggest that EBV may pay a role in the development of HCC.
出处
《中国医师杂志》
CAS
2003年第11期1451-1453,共3页
Journal of Chinese Physician
基金
广东省科技计划基金项目 (2KMO450 4s)
关键词
肝肿瘤
疱疹病毒4型
人
肝炎病毒
Neoplasms,Liver
Herpesvirus-4,Human
Virus,Hepatitis
