摘要
目的 :观察创伤性休克大鼠血浆肾上腺髓质素 (AM)与血管阻力的变化 ,探讨 AM在创伤性休克病理生理过程中的作用。方法 :应用放射免疫法检测创伤性休克大鼠血浆 AM浓度 ,采用生物电阻抗方法测定平均动脉压 (MAP)、总外周血管阻力 (TPVR)和心脏指数 (CI)。结果 :休克复苏与未复苏组血浆 AM浓度分别为(1 4 6 .2 7± 9.83) ng/ L和 (6 8.34± 3.71 ) ng/ L ,均明显高于对照组 (32 .6 2± 7.5 5 ) ng/ L (P<0 .0 1和 P<0 .0 5 )。休克复苏组 TPVR为 (1 0 .5 7± 0 .35 ) k Pa· s· L- 1 ,明显低于休克未复苏组 (1 6 .75± 0 .2 3) k Pa· s· L- 1 (P<0 .0 1 ) ;CI明显高于休克未复苏组〔(2 1 5 .5 9± 1 .2 9) ml· min- 1· kg- 1比 (1 4 3.1 1± 0 .86 ) ml· m in- 1· kg- 1 ,P<0 .0 1〕。结论 :AM与血管阻力变化密切相关 。
Objective: To observe the changes of adrenomedulin in plasm and vascular resistance during traumatic shock in rats. Methods: The concentration of adrenomedulin in plasm of rats after traumatic shock was detected by radio immunization. Mean arterial pressure, total peripheral vascular resistance(TPVR) and cardiac index(CI) were estimated by electrical conductance method. Results: The concentration of adrenomedulin in plasm of traumatic shock without resuscitation group(68 34±3 71)ng/L and traumatic shock with resuscitation group (146 27±9 83)ng/L were higher than that of control group(32 63± 7 55)ng/L ( P <0 01 and P <0 05). TPVR of traumatic shock with resuscitation group (10 57± 0 35) kPa·s·L -1 was lower than that of traumatic shock without resuscitation group (16 75± 0 23) kPa·s·L -1 ( P <0 01) and its CI (215 59±1 29) ml·min -1 ·kg -1 was higher than that of traumatic shock without resuscitation group (143 11±0 86) ml·min -1 ·kg -1 ( P <0 01). Conclusion : Adrenomedulin is closely correlated with changes of vascular resistance and plays an important role during pathophysiological processes in rats after traumatic shock.
出处
《中国危重病急救医学》
CAS
CSCD
2003年第12期751-753,共3页
Chinese Critical Care Medicine
基金
广东省自然科学基金资助项目 ( 0 0 10 48)
