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失血性休克患者血浆肾上腺髓质素与血管阻力变化的关系 被引量：3

The relationship between plasma adrenomedullin levels and vascular resistance in patient with hemorrhagic shock
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摘要 目的　观察失血性休克患者血浆肾上腺髓质素 (ARM)与血管阻力变化 ,探讨ARM在失血性休克病理生理过程中的作用。方法　应用放射免疫检测 30例休克患者血浆ARM浓度 ,无创胸导生物电阻抗方法测定平均动脉压 (MAP)、全身血管阻力指数 (SVRI)和心脏指数 (CI)。结果　休克组治疗前血浆ARM浓度明显高于正常对照组 (P <0 0 1)。结论　ARM与血管阻力变化相关 。 Objective To investigate the relationship between plasma adrenomedullin (ARM) level and systemic vascular resistance index (SVRI),and their role in the pathogenesis of hemorrhagic shock.Methods Plasma ARM levels were measured in 30 patients with hemorrhagic shock by specific radioimmunoassay.And measurements of mean blood pressure,SVRI,cardiac index (CI) were noninvasively performed by electrical bioimpendane.Results Plasma ARM levels were significantly higher in hemorrhagic shock group than that in control group (P<0.01).Conclusions The results indicate that ARM appears to be associated with SVRI,which might plays an important role in hemodynamics of shock.
作者 王毅伟 朱玉琦 赵金英 林世升 张利军
机构地区 哈尔滨医科大学附属第一医院麻醉科 哈尔滨医科大学附属第一医院检验科
出处 《临床麻醉学杂志》 CAS CSCD 2002年第5期248-249,共2页 Journal of Clinical Anesthesiology
关键词 肾上腺髓质素 失血性休克 血液动力学 血管阻力 Adrenomedullin Hemodynamics Vascular resistance Shock
分类号 R605.971 [医药卫生—急诊医学]
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参考文献7

  • 1[1]Kitamura K,Kangawa K, Kawamoto M,et al. Adrenomedullin:a novel hypotensive peptide isolated from human pheochromocytoma.Biochem Biophys Commun,1993,192:553-557.
  • 2[2]Sugo S,Minamino N,Shoji H,et al.Interleukin-1,tumor necrosis factor and lipopolysaccharide additively stimulae prodution of adrenomedullin in vascular smooth muscle cells.Biochem Biophys Res Commun,1995,215:531-537.
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同被引文献22

  • 1Malay MB, Ashton JL, Dahl K, et al. Heterogeneity of the vasoconstrictor effect of vasopressin in septic shock. Crit Care Med, 2004,32:1327-1331.
  • 2Holmes CL, Patel BM, Russell JA, et al. Physiology of vasopressin relevant to management of septic shock. Chest, 2001,120: 989-1002.
  • 3Mutlu GM, Factor P. Role of vasopressin in the management of septic shock. Intensive Care Med, 2004,30 : 1276-1291.
  • 4Jochberger S, Mayr VD, Luckner G, et al. Serum vasopressin concentrations in critically ill patients. Crit Care Med, 2006,34 : 293-299.
  • 5Dunser MW, Mayr AJ, Tur A, et al. Ischemic skin lesions as a complication of continuous vasopressin infusion in catecholamineresistant vasodilatory shock: incidence and risk factors. Crit Care Med, 2003,31 : 1394-1398.
  • 6Wiesenac kC, Prasser C, Rodig G, et alo Stroke volume variation as an indicator of fluid responsiveness using pulse contour analysis in mechanically ventilated patients. Anesth Analg, 2003,96: 1254-1257.
  • 7RIVERS E, NGUYEN B, HAVSTAD S, et al. Early Goal-Directed therapy in the treatment of severe sep- sis and septic shock[J]. N End J Med,2001,345:1368 -1377.
  • 8ALSOUS F, KHAMIEES M, DEGLMLAMO A, et al. Negative fluid balance predicts survival in patients with septic shock: a retnrspective pilot study[J]. Chest, 2000,117 :1749- 1754.
  • 9LOPEZ-HERCE J, BUSTINZA A, SANCHO L, et al. Cardiac output and blood volume parameters using femoral arterial thermodilution[J]. Pediatr Int, 2009, 51:59-59.
  • 10SINGARAJAH C,CARLSON R. A review of the role the blood lactate measurements in the ICU[J]. Inten- sive Care Med,1998,13:218-228.

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临床麻醉学杂志
2002年 第5期

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