摘要
目的 :研究组成药物相同、但配比不同的三方 :小承气汤、厚朴大黄汤及厚朴三物汤的药理作用差异 ,为其临床不同应用提供依据。方法 :采用炭末推进、黑便排出、氨水引咳、酚红分泌等理气、泻下及止咳化痰等有关实验。结果 :三方大剂量均显著增加炭末在小肠推进距离 ,小剂量时仅厚朴三物汤有效且与小承气汤差异显著 ;三方大剂量均显著缩短小鼠出现黑便时间 ,增加 6h内黑便排出总量 ,小剂量时小承气汤、厚朴大黄汤即呈现明显泻下作用 ,厚朴三物汤无效 ;厚朴大黄汤明显延长小鼠咳嗽潜伏期 ,减少咳嗽次数 ,并显著促进小鼠气管酚红排泌 ,而其它两方作用不明显。结论 :小承气汤泻下作用较强 ,厚朴三物汤理气效果较好 。
AIM: To observe the difference of actions among three traditional compl ex prescriptions with the same composition but the different dosage, including X iaochengqi Decoction, Houpudahuang Decoction and Houpusanwu Decoction, so as to provide evidence for their different clinical applications. METHODS: A series of experiments were performed, including carbon p rop ellance in small intestine, black stool excretion, cough induced by ammonia liqu or and phenol red secretion from trachea. RESULTS: Three prescriptions all enhanced carbon propellance in sma ll intestine at the high dosage, while at the low dosage only Houpusanwu Decoct ion showed the significant effect. They all shortened the latency of black stool a nd increased their total amounts in 6 hours at the high dosage, while at the low dosage Xiaochengqi Decoction and Houpudahuang Decoction had the significant p urgative action. Houpudahuang Decoction remarkably prolonged cough latency, dec reased cough times and enhanced phenol red secretion from trachea, while other t wo prescriptions had no obvious effects. CONCLUSION: Such results showed that Xiaochengqi Decoction had the better purgative action, while Houpusanwu Decoction regulated Qi strongerly, a nd Houpudanghuang Decoction showed the marked actions of relieving cough and re solving phlegm.
出处
《中成药》
CAS
CSCD
北大核心
2004年第1期57-59,共3页
Chinese Traditional Patent Medicine
关键词
小承气汤
厚朴大黄汤
厚朴三物汤
理气
泻下
止咳化痰
Xiaochenqi Decoction
Houpusanwu Decoction
Houpudahuang Decoction
regulate Q i
purgative
relieve cough
resolve phlegm
