摘要
目的 探明昆明山海棠的急性毒性及半数致死剂量 (LD50 ) ,为临床的安全使用提供依据和资料。方法 THH水提液多剂量小鼠口服 ,观察小鼠的死亡率和脏器的感官病理改变。结果 雄性的LD50 ( 95 %可信限 )为 79g kg( 69～ 89g kg) ,雌性的LD50 ( 95 %可信限 )为 10 0g kg ( 90～ 112g kg) ;肉眼未见脏器明显的病理改变。结论 按化学物质的急性毒性分级标准 ,THH水提液属中等毒级别 ,临床使用比较安全 。
Objective To explore the acute toxicity and LD 50 of Tripterygium Hypoglaucum (Levl) Hutch(THH) solution to provide information for safe clinical application. Methods After oral administration of THH solution in mice, the mortality and the physiological and pathological changes were observed. Results The LD 50 (95% confidence limit) of THH in male and female mice was 79 g/kg(69～89 g/kg) and 100 g/kg (90～112 g/kg), respectively. No marked pathological change of the organs was found. Conclusion According to the standard of grading of acute toxicity, THH solution belongs to the moderate class. Therefore, it is safe in clinical practice and has a wide application.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2003年第17期1524-1526,共3页
Journal of Third Military Medical University
基金
德国联邦教育科学研究技术部 (BMBF)基金资助项目
国家自然科学基金资助项目 (C30 10 0 2 4 1)
第三军医大学中青年科研基金资助项目 ( 2 0 0 0 2 0 0 1)
关键词
昆明山海棠
急性毒性
LD50
Tripterygium Hypoglaucum (Levl) Hutch
acute toxicity
LD 50
