摘要
目的 :研究双黄连对氨茶碱在人体内药动学的影响。方法 :采用高效液相色谱法测定8名健康志愿者多剂量服用双黄连口服液前、后氨茶碱的血药浓度 ,以3p97药动学软件按一室模型对数据进行处理 ,并对结果进行统计学分析。结果 :单用氨茶碱和合用双黄连后氨茶碱的Tmax 分别为 (1 66±0 56)、(1 59±0 78)h ,Cmax 分别为 (6 23±1 31)、(6 10±0 94) μg/ml ,T1/2 分别为(5 76±1 11)、(6 09±1 63)h ,CL分别为 (47 72±5 12)、(50 98±10 85)ml/(kg·h) ,Vd分别为 (369 18±40 15)、(430 37±48 33)ml/kg,AUC0→∞分别为 (84 56±14 43)、(89 27±26 35) μg/(h·ml)。结论 :双黄连明显增加氨茶碱的Vd ,对Tmax、Cmax、T1/2。
OBJECTIVE:To study the effects of Shuanghuanglian on pharmacokinetics of theophylline in healthy subˉjects.METHODS:The serum concentration of theophylline was determined by HPLC and analyzed by3p97pharmacokinetic program.RESULTS:The main pharmacokinetic parameters of single theophylline and that in combined use with Shuanghuanˉglian were as follows:T max were(1.66±0.56)and(1.59±0.78)h,C max were(6.23±1.31)and(6.10±0.94)μg/ml,T 1/2 were(5.76±1.11)and(6.09±1.63)h,CL were(47.72±5.12)and(50.98±10.85)ml/(kg·h),Vd were(369.18±40.15)and(430.37±48.33)ml/kg,AUC 0～∞ were(84.56±14.43)and(89.27±26.35)μg/(h·ml),respectively.CONCLUSION:The Vd of theophylline were increased(P<0.05)in combined use with Shuanghuanglian.There were no effects of Shuanghuanglian on T max ,C max ,T 1/2 ,CL,AUC 0～∞ of theophylline.
出处
《中国药房》
CAS
CSCD
2003年第10期606-607,共2页
China Pharmacy
