摘要
目的 :观察草分枝杆菌胸腔内注射治疗恶性胸腔积液的近期疗效、毒副反应及其对患者T淋巴细胞亚群水平的影响。方法 :将 6 2例恶性胸腔积液患者随机分成试验组和对照组 ,先尽量排完胸腔积液 ,试验组向胸腔内注射生理盐水 2 0ml +草分枝杆菌 8.6 μg+顺铂 4 0mg ;对照组向胸腔内注射生理盐水 2 0ml +顺铂 4 0mg ,每周 1次 ,连续 1～ 3次 ,1mon后观察疗效及治疗前后T淋巴细胞亚群水平变化。结果 :试验组总有效率为 87.5 % ,高于对照组 (P <0 .0 1) ,毒副反应少而轻微。治疗后CD+3 、CD+4及CD+4 CD+8明显升高 (P <0 .0 1或 0 .0 5 ) ,CD+8显著降低 (P <0 .0 1)。结论 :草分枝杆菌联合顺铂治疗恶性胸腔积液疗效肯定 ,副反应少 ,且能明显改善患者T淋巴细胞亚群抑制状态。
AIM: To evaluate the efficacy, safety and effects on changes of T lymphocyte subsets of mycobacterium phlei and cisplatin in treatment of patients with malignant pleural effusion (MPE). METHODS: 62 patients of MPE were randomly assigned to two groups. The test group was treated once a week lasting for 1-3 weeks with NS 20 ml + mycobacterium phlei 8.6 μg + cisplatin 40 mg, while the control one with NS 20 ml + cisplatin 40 mg only. The efficacy and changes of T lymphocyte subsets before and after therapy were analyzed separately. RESULTS: The overall response rate in the test group was 87.5 %, which meant significantly higher than that in the control group (P< 0.01 ), and the side effects were mild. After the treatment, the levels of CD + 3 and CD + 4 cells and the ratio of CD + 4/CD + 8 increased greatly (P< 0.05 or 0.01 ), while the level of CD + 8 dropped sharply (P< 0.01 ). CONCLUSION: The therapy of mycobacterium phlei combined with cisplatin is effective in controlling the MPE with low side effect, and can greatly improve the inhibition of T lymphocyte subsets in patients with MPE.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2004年第1期107-109,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
草分枝杆菌
顺铂
恶性胸腔积液
T淋巴细胞亚群
细胞免疫
协同效应
mycobacterium phlei
cisplatin
malignant pleural effusions
T lymphocyte subsets
cellular immunity
immunotherapy
synergisitic effect
