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铁在大鼠黑质多巴胺能神经元损伤中作用研究 被引量：3

Experimental Study of the Role of Iron in the Course of Dopaminergic Neurons
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摘要 目的　观察铁在多巴胺能神经元损伤过程中的作用 ,并探讨铁在帕金森病 (Parkinson disease,PD)起病阶段的作用。方法　通过 PD大鼠模型 ,采用生化、TUNEL方法观察 6-羟基多巴胺 (6-OHDA)脑立体定向注射1、7、1 4、2 1 d PD黑质铁浓度、自由基以及黑质细胞凋亡数变化。结果　 1～ 2 1 d PD大鼠黑质铁浓度、自由基及凋亡细胞数随时间增加而增加 ,并显著高于对照组。结论　铁在 PD发病中具有重要作用。 Objective To observe the role of iron in the course of the injury of dopaminergic neuron and explore the effect of iron in the episode of Parkinson disease.Methods At 1,7,14,21 d after rats were injected stereotaxically by 6 OHDA, we applied biochemistry, TUNEL methods to observe the intensity of iron, and free radicals, and number of apoptosis of substancial nigra of rats with Parkinson disease(PD).Results From 1 21 d, in the group of PD rats, the concentrations of fetal, free radical, and number of apoptosis of substantial nigra were increased gradually in pace with days of 6 OHDA injected stereotaxically.Conclutions Iron plays an important role in the episode of Parkinson disease.
作者 曹非 孙圣刚 童萼塘 骆芳
机构地区 华中科技大学同济医学院附属协和医院神经内科 湖北省新华医院内科
出处 《中国神经免疫学和神经病学杂志》 CAS 2003年第2期129-132,共4页 Chinese Journal of Neuroimmunology and Neurology
基金 2 0 0 0年湖北省自然科学基金资助项目 (2 0 0 0 J0 49) 1998卫生部科学研究基金课题资助项目 (98-2 -10 5 )
关键词 铁 多巴胺能神经元 帕金森病 自由基 细胞凋亡 发病机制 动物模型 Parkinson disease fetal apoptosis
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献7

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同被引文献31

  • 1李郁欣,耿道颖,蒋雨平,沈黎玮,朱珍.基底节、黑质的MRI体积测量在帕金森病中的应用研究[J].中国医学计算机成像杂志,2006,12(1):6-10. 被引量：11
  • 2[1]Kitada T, Asakawa S, Hattori N, et al . Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism[J]. Nature, 1998,392(6676): 605 ～ 608.
  • 3[2]Olanow C W, Tatton W G. Etiology and pathogenesis of Parkinson' s disease[J]. Annu Rev Neurosci,1999,22:123 ～ 144.
  • 4[3]Ted M, Dawsonand, Valina L, et al .Rare genetic mutations shed light on the pathogenesis of Parkinson disease[J].J Clin Invest,2003,111:145～ 151.
  • 5[4]Solano S M,Miller D W,Augood S J, et al .Expression of alpha - synuclein, parkin, and ubiquitin carboxy- terminal hydrolase L1 mRNA in human brain:genes associated with familial Parkinson' s disease [ J ].Ann Neurol,2000,47(2) :201 ～ 210.
  • 6[5]Merad - Boudia M, Nicole A, Santiard - Baron D, et al . Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson' s disease [ J ].Biochem Pharmacol, 1998,56(5) :645 ～ 655.
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  • 10[10]Blandini F, Nappi G, Tassorelli C, et al .Functional changes of the basal ganglia circuitry in Parkinson' s disease[J]. Prog Neurobiol, 2000,62( 1 ): 63～ 88.

引证文献3

二级引证文献15

中国神经免疫学和神经病学杂志
2003年 第2期

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