摘要
本文报告用多氯联苯(PCB)200mg/kg对大鼠连续腹腔注射三日染毒,除可诱导肝脏微粒体乙氧基异吩噁唑脱乙基酶(EROD)活性增高外,在脾脏微粒体内也检出EROD活性(4.9pmol/min·mg蛋白质)。当PCB剂量为400mg/kg时,大鼠脾脏S_9组分中EROD活性为对照组的3.3倍。结果说明尽管脾脏本底的细胞色素P-448活性极低,但仍可被化学致癌物PCB诱导。
Male Wistar rats were treated with Polychorinated biphenyls ( PCB ) via an intrapertion-eal injection for 8 consecutive days. Ehoxyresoruf in O-deethylase (EROD ) activity(4.9Pmol /min/mg protein ) was found in the microsome from PCB-induced animals. EROD activity was also induced in rat spleen S9 fractions after the treatment with PCB (400mg/kg ) , an inductive ratio of 3.3 was produced. These results indicate that rat lymphoid tissue cells can respond to chemical insults such as PCB can induce a cytochrome P-448 inductive response.
出处
《卫生毒理学杂志》
CAS
CSCD
1992年第1期29-31,共3页
Journal of Health Toxicology
关键词
多氯联苯
EROD
脾
细胞色素
Polychlorinated biphenyls
lSpeen S9 fraction
Ethoxyresorufin O-deethylase
Cytochrome P-448
