摘要
对兔出血症的凝血象和组织病理学动态研究以及肝素对兔出血症弥漫性血管内凝血（ＤＩＣ）影响的探讨，建立了兔出血症病毒（ＲＨＤＶ）诱发兔ＤＩＣ的动物模型。该模型与ＤＩＣ模型建立标准完全吻合，并具有以下特点：１有典型的皮下出血，精神沉郁，抽搐等临床症状。２凝血象有ＤＩＣ典型变化，并呈规律的动态发展过程，感染后６ｈ是高凝期，１８ｈ进入低凝期。３全身器官均可检到典型的微血栓，肺、肾最多。感染后１２ｈ为血栓检出高峰期，２４ｈ或死兔以出血为主，表现为纤溶亢进的特征性变化。４肝素处理的攻毒兔微血栓少见，发病轻微，死亡率低，表明肝索可以阻断兔出血症ＤＩＣ的发生。三批攻毒兔的凝血象呈一致变化，证明ＲＨＤＶ诱发的兔ＤＩＣ重复性高，稳定性好，是一个比较理想的病毒诱发ＤＩＣ的动物模型。兔出血症，兔出血症病毒，弥漫性血管内凝血。
AbstractAn animal modele for disseminated intravascular coagulation ( DIC ) inrabbits was established with rabbit hemorrhagic disease virus ( RHDV ) This modele has the following features: 1 typical subcutaneous hemorr-hage, 2 Characteristic coagulation changes, 3 microthrombins foundin all organs, maximum numbers in Lungs, and 4 DIC could partly beprevented by heparin. The results of coaguiation assay on thrae groupsof inoculated rabbits wsre identical. The study suggests that the animalmodele for RHDV-induced DIC might be repeated and stable.
出处
《中国实验动物学报》
CAS
CSCD
1995年第1期51-54,共4页
Acta Laboratorium Animalis Scientia Sinica
