摘要
目的 为获得 15个基因座在台湾汉族群体中的遗传学数据 ,探究其在法医学检验中的应用价值。 方法 用ProwerPlex(r) 16System荧光标记试剂盒 (Promega公司 )检测 15个STR基因座的多态性。 结果 在 189例台湾汉族随机个体中 ,15个STR基因座分别检出 6、7、15、15、19、10、8、8、7、8、10、8、9、6、19个等位基因 ,各等位基因频率为 0 .0 0 2 6～ 0 .452 4。观察杂合度 (HO)为 0 .60 82～ 0 .92 61,期望杂合度 (HE)为 0 .610 3～ 0 .9162 ,多态信息含量 (PIC)为 0 .5491～ 0 .90 73 ,亲权排除率 (PE)为 0 .3 53 2～ 0 .82 64,个体识别率为 0 .60 91～ 0 .914 3。累积亲权排除率 (PE)为 0 .999999,累积个体识别率为 0 .999999999。 结论 该15个STR基因座具有很高的多态性 。
Objective In order to obtain the genetic po lymorphism data of 15-STR loci in Taiwan Han population. Methods The 15 loci were analysed by using the method of PowerPlex(r) 16 system and Genscan software. Results 6～19 alleles was found i n Taiwan Han population .The expected heterozygosity of 15 loci was 0.610 3～0.9 16 2, the polymorphism information content was 0.549 1～0.907 3, power of exclus ion was 0.353 2～0.826 4, the discrimination power was 0.609 1～0.914 3. Total power of exclusion was 0.999 999 and total discrimination power was 0.999 999 99 9. Cconclusion The result shows that the 15 loci were hi ghly informative and suitable for forensic application.
出处
《法律与医学杂志》
2003年第4期245-247,共3页
Journal of Law & Medicine
