摘要
目的 :探讨抗胃食管反流治疗对伴有胃食管反流 (GER)的慢性阻塞性肺病 (COPD)患者肺通气功能的影响。方法 :12 1例COPD患者检测出合并GER 87例。将合并GER的 87例随机分为 2组 :组 1 4 3例 ,组 2 4 4例 ,不伴有GER的 34例列为组 3。组 1仅给予盐酸溴己新 16mg,tid,硫酸特布他林 2 .5mg,3次 /d及抗生素治疗 ,疗程 4周。组 2、组 3在给予上述相同药物 (剂量相同 )治疗的同时 ,加服奥美拉唑 2 0mg ,bid及西沙必利 10mg,3次 /d ,疗程 4周。 3组病例治疗前、后均行肺通气功能检测。结果 :治疗后组 2的各项肺通气功能指标均显著高于组 1、组 3(P <0 .0 5 )。组 1、组 3的各项肺通气功能指标在治疗前后均无显著差异(P >0 .0 5 )。组 2治疗后各项肺通气功能指标均显著高于治疗前 (P <0 .0 1)。结论 :伴有GER的COPD患者常规治疗方案中加用抑酸剂和胃肠动力药抗反流治疗 。
Objective: To study the effect of anti-GER treatment on the lung ventilation function of the patients with chronic obstructive pulmonary disease (COPD) with gastro-esophageal reflux(GER). Methods:121 patients of COPD were divided into three groups at random. The first group including 43 cases with GER received treatment with bromhexini hydrochloride (16mg, 3 times/day) and terbutalini sulfate (2.5mg, 3 times/day) and antibiotics. The second group including 44 cases with GER and third group of 34 cases without GER added omeprazole (20mg, 2 times/day) and cisapride (10mg, 3 times/day) on basis of treatment as group 1. The treatment period was 4 weeks. The lung ventilation function was measu-red for all of the three groups before and after study. Results: The lung ventilator function of the second group was significantly better than that of the first and third group (P<0.05) after the treatment. There was no significant difference of all of the parameters of the lung ventilation function for the first and third group before and after treatment (P>0.05). On the contrary, all the parameters of the lung ventilation function of the second group were significantly improved after the treatment (P<0.01). Conclusion:On the basis of routine therapy antacids and gastronitestinal prokinetic agents may improve the lung ventilation functionof the patients of COPD with GER.
出处
《中国临床医学》
2003年第6期821-822,832,共3页
Chinese Journal of Clinical Medicine
