摘要
目的了解胃食管反流(GER)在慢性阻塞性肺疾病急性加重(AECOPD)住院患者中的发病率,以及GER对AECOPD患者气道酸碱度及肺通气功能的影响。方法选择AECOPD住院患者65例,根据《反流问卷调查表》结果分为GER阳性组和GER阴性组;同时选择健康人20例作为对照组。检测三组呼出气冷凝液(EBC)pH值和肺通气功能(FEV1、FEV1/FVC、FEV1%pred)。结果AECOPD合并GER的发病率为30.8%(20/65)。GER阳性和GER阴性AECOPD患者在年龄、性别、体重指数(BMI)、血浆白蛋白(Alb)、血气(PaCO2、PaO2)等方面无显著差异(P均>0.05)。GER阳性AECOPD患者EBC的pH值显著低于GER阴性AECOPD患者和对照组[6.00±0.75比6.76±0.77和7.97±0.12,P均<0.05],GER阴性AECOPD患者也显著低于对照组(P<0.05)。GER阳性AECOPD患者肺通气功能显著低于GER阴性组。结论AECOPD患者存在一定程度的气道酸化,GER在AECOPD患者中有较高的发病率,GER使AECOPD气道酸化更明显,并可能是促进COPD发生发展的重要因素。
Objective To investigate the prevalence of gastroesophageal reflux （GER） in acute exacerbation of chronic obstructive pulmonary disease（AECOPD） and to explore the influence of GER on the acidity of airway and pulmonary ventilation function in AECOPD patients. Methods Sixty-five hospitalized AECOPD patients and 20 healthy volunteers were enrolled in this study. According to ＂GER survey＂ questionnaire,AECOPD patients were allocated into GER group and non-GER group and expired breath condensate（EBC） pH and pulmonary ventilation function were detected. Breath condensate samples were collected using a specially designed condensing chamber（ EcoScreen, Germany）. Results About 30. 8% （20/65） AECOPD patients were complicated with GER. EBC pH was lowest in GER group,middle in non-GER group and highest in the control group [6.00 ± 0.75 vs 6. 76 ±0. 77 and 7.97 ± 0. 12, both P 〈 0. 05 ）. The pulmonary ventilation function（ FEV1 ,FEV1% pred） in AECOPD patients with GER were lower than those without GER （ both P 〈 0. 05 ）. Conclusions There is a high prevalence of GER in AECOPD patients. And the airway pH is reduced in AECOPD patients, especially when complicated with GER, which may play an important role in the development of COPD.
出处
《中国呼吸与危重监护杂志》
CAS
2008年第6期448-451,共4页
Chinese Journal of Respiratory and Critical Care Medicine
关键词
慢性阻塞性肺疾病
急性加重
胃食管反流
气道
呼出气冷凝液
pH
肺功能
Chronic obstructive pulmonary disease
Acute exacerbation
Gastroesophageal reflux
Airway
Expired breath condensate
pH
Lung function
