摘要
目的 :探讨参附注射液对体外循环下法乐四联症 (TOF)根治术患者的心脏保护作用。方法 :选择体外循环下行 TOF根治术患者 96例 ,随机分为参附组 (n=4 8)和对照组 (n=4 8) ,参附组麻醉前 30 m in静脉输入参附注射液 1ml/ kg,对照组输入等量生理盐水。观察术中血流动力学及脉搏血氧饱和度 (Sp O2 )变化 ,术中及术后血管活性药物的使用及术后康复时间。结果 :参附组术中平均动脉压 (MAP)及 Sp O2 高于对照组 ,心率(HR)、中心静脉压 (CVP)低于对照组 (P均 <0 .0 5 ) ;参附组术中及术后多巴胺、多巴酚丁胺、硝普钠、西地兰使用剂量低于对照组 (P均 <0 .0 5 ) ;参附组术后拔管时间、ICU留置时间短于对照组 (P均 <0 .0 5 )。结论 :参附注射液对体外循环下法乐四联症根治术患者的心功能有一定保护作用。
Objective:To investigate whether Shenfu injection(参附注射液) has protective effect on cardiac function in patients undergoing Fallot's tetrad radical operation under cardiopulmonary bypass. Methods: Ninetysix patients undergoing Fallot's tetrad radical operation were randomly divided into Shenfu injection(SF) group and control group. The SF group was treated with 1 ml/kg Shenfu injection intravenous at 30 minutes before anesthesia, the control group was infused with 1 ml/kg saline intravenously. The changes of hemodynamics and pulse oxygen saturation(SpO 2) during surgery, dose of vasoactive drugs intra and postoperatively, recovery time during postoperative period were observed. Results: In SF group, mean artery pressure(MAP) and SpO 2 were higher and heart rate(HR), central venous pressure(CVP) were lower (all P<0.05), the doses of dopamine, dobutamine, sodium nitroprusside and cedilanid were lower intra and postoperatively (all P<0.05), and the extubation time and ICU stay time were shorter during postoperative period (all P<0.05) than those in control group. Conclusion: Shenfu injection has protective effect on cardiac function in patients undergoing Fallot's tetrad radical operation.
出处
《中国中西医结合急救杂志》
CAS
2003年第6期326-329,共4页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
卫生部 999中药注射液科研基金资助项目 ( 2 0 0 3 12 )
