摘要
目的 :探讨血清基质金属蛋白酶 2 (MMP- 2 )和肿瘤坏死因子 α(TNF- α)在糖尿病肾病 (DN)发病中的作用。方法 :以酶联免疫法测定糖尿病肾病 (DN)患者和正常对照者血清基质金属蛋白酶 2 (MMP- 2 ) ,以放免分析法测定肿瘤坏死因子 α(TNF-α) ,以尿白蛋白排泄率 (UAER)判断 DN的严重程度。结果 :血清 MMP- 2随 DN的严重程度呈降低趋势 ,TNF-α随DN的严重程度而明显升高。结论 :MMP- 2、TNF- α可能参与
Objective:To study the role of metalloproteinase matrix-2(MMP-2),tumor necrotic factor-α(TNF-α)in diabetic patients with nephropathy.Methods:Serum metalloproteinase matrix-2(MMP-2) levels were measured by ELISA in diabetic patients with nephropathy and normal control , TNF-α was measured by radiommunoassay ,and the severity of DN was determined by urinary albumin excretion rate. Results: Serum metalloproteinase matrix-2(MMP-2) levels decreased with the severity of DN,while TNF-α often to increased. Conclusion:Netalloproteinase matrix-2(MMP-2)and tumor necrotic factor-α(TNF-α)seem to participate in the pathogenesis of DN.
出处
《黑龙江医药科学》
2003年第6期12-13,共2页
Heilongjiang Medicine and Pharmacy
