摘要
目的 :探讨急进高海拔地区机体对低压、低氧环境的适应机制 ;方法 :将海拔1 0m处的平原大鼠快速带至海拔 2 2 61m ,再带入海拔 3 80 0m处 ,用放射免疫法测定大鼠血浆肾素、血管紧张素Ⅱ和醛固酮的浓度 ;结果 :随海拔递增①大鼠肾素及血管紧张素Ⅱ含量呈上升趋势 ,醛固酮浓度逐渐下降 ,统计学处理有显著性差异 ;②急进高海拔地区 ,醛固酮对血管紧张素Ⅱ的反应钝化 ,使醛固酮处于低水平状态 ;结论 :上述结果提示 :急进高海拔 ,机体对水、电解质的调节会发生变化 。
Objective:To study the adaptive mechanism of a body getting into the altitude area rapidly adapts itself to the depression and hypoxia environment. Methods: Thirty rats were exposed rapidly to Xining (altitude of 2 261m) and Tianjun (altitude of 3 800m) from Qindao (sea level of 10m), and the plasma level of rennin, angiotensin Ⅱ and aldosterone were dynamically examined by the radioimmunoassay. Results: The plasma level of rennin and angiotensin Ⅱwere increased and aldosterone was decreased with the higher altitude. Conclusion: The RAA system can regulate its function to adapting the high altitude environment in the rats exposed acutely to the altitude from low level through the bio-active substances.
出处
《高原医学杂志》
CAS
2003年第4期20-22,共3页
Journal of High Altitude Medicine
