摘要
目的 :了解一氧化氮 (NitricOxide,ON)对急性高原病患者血清白介素 -8(In terleuk -8,IL -8)的影响及意义 ;方法 :将 47例急性高原病患者随机分为两组 ,一组为药物治疗组 (2 3例 ) ,另一组为NO治疗组 (2 4例 ) ,药物治疗组给予吸氧、氨茶碱、地塞米松、速尿等药物常规治疗 ,NO治疗组给予吸入由海拔 3 658m高度的空气平衡的 1 0 ppm的NO气体 ,每天 2次 ,上午、下午各 1h ,并利用放射免疫法对两组急性高原病患者治疗前后血清IL -8含量进行检测比较 ;结果 :NO治疗组治疗后的血清IL -8含量显著低于NO治疗组治疗后和药物治疗组治疗后的血清IL -8含量 (分别为 :P <0 .0 0 1、P <0 .0 1 ) ,药物治疗组治疗前后比较差别亦具有显著性 (P <0 .0 5) ;结论 :NO能抑制急性高原病患者IL -8的分泌 。
Objective: To research the change and significance of NO on the quantity of serum interleuk-8(IL-8) in patients with acute high altitude disease; Method: 47 patients were divided into medicinal group( n =23) and NO group( n =24). The medicinal group was treated with oxygen, Aminophylline, Dexamethasone, Furosemide. The NO group was treated with breathing No balanced by the air of the altitude of 3 658m, twice a day.The serum level of interleuk-8 was measured using Radioimmunoassay (RIA) before and after treatment and comparison was performed between both groups. Results: The quantity of serum interleuk-8 in the No group was lower after treatment than that before treatment and it was lower than that after treatment of the medicinal group ( P <0.001、 P <0.01). There was a statistics significance( P <0.05)of quantity of serum interleuk-8 in the medicinal group between before and after treatment. Conclusion: Nitric oxide can reduce the secretion of serum interleuk-8 of the patients with high altitude disease and it is beneficial for convalesce of the patients.
出处
《高原医学杂志》
CAS
2003年第4期17-19,共3页
Journal of High Altitude Medicine
