摘要
目的 :探讨海拔 540 0m高原富氧对纠正低氧大鼠学习记忆功能持续时间的作用 ;方法 :3月龄Wistar大鼠 2 2只随机分为低氧组 (1 2只 )和富氧组 (1 0只 ) ,低氧组在模拟海拔 540 0m的低压舱内 2 4小时 ,富氧组在模拟海拔 540 0m的低压舱内 1 2小时富氧(2 7%的氧混合气 ) 1 2小时 ,于出富氧室即刻、2h、4h、6h分别进行Morris水迷宫试验测定大鼠的学习记忆能力 ;结果 :与低氧组比较 ,富氧组寻找平台潜伏期的时间缩短 ,低氧组运动水迷宫游泳呈周边型 ,富氧组呈向平台型 ,出富氧室 4h ,学习记忆功能仍明显高于急性缺氧组 ;结论 :富氧能改善缺氧大鼠的学习记忆功能 ,增加机体的氧储备 。
Objective:To investigate the effect of oxygen-enrichment on improvement of lasting learn memory function of hypoxic rats at altitude of 5 400m.Methods: In this randomized trial, 22 Wistar rats aged 3 months old were divided into hypoxia group ( n =12)、oxygen-enrichment group ( n =10).The hypoxia group was put in low oxygen pressure chamber (simulating altitude of 5 400m) for 24 hours; the oxygen-enrichment group stayed in the oxygen-enrichment room (27% of oxygen concentration) for 12 hours. The Morris water labyrinth test was performed to estimate the learning memory ability after 0、2、4、6h oxygen-enrichment. Results: In contrast to hypoxia group, the oxygen-enrichment group took shorter time to reach the platform. In water labyrinth test, the swimming routes of oxygen enrichment group were much more inclining to the platform than that in the hypoxia group. The learning memory function of hypoxic rats was also much better than the hypoxia group after 4h oxygen-enrichment. Conclusion: Oxygen-enrichment can improve learning memory function of hypoxic rats and increase the body oxygen reserve so that it results in a very important application value in high altitude military medicine.
出处
《高原医学杂志》
CAS
2003年第4期6-9,共4页
Journal of High Altitude Medicine
