摘要
目的 :探讨进驻高原不同海拔高度不同居住时间健康青年血浆C型利钠肽 (C -typenatriureticpeptideCNP)和心房利钠肽(AtrialnatriureticpeptideANP)的变化。方法 :对从平原进驻海拔 370 0m和 5 380m高原第 7d及 6个月的 40名边防某部官兵 ,应用放射免疫分析法检测其血浆CNP、ANP含量 ,并与 2 0名平原健康青年作对照。结果 :进驻海拔 370 0m和 5 380m的第 7天及 5 380m 6个月较平原CNP、ANP均增高显著 (P <0 .0 5或P <0 .0 1) ,370 0m居住 6个月时较平原ANP增高显著 (P <0 .0 1) ,CNP无统计学差异 (P >0 .0 5 )。且随海拔高度的升高而增高 (P <0 .0 5或P <0 .0 1) ,初入高原时明显高于在高原居住 6个月者 (P <0 .0 1)。结论 :CNP和ANP对急、慢性高原缺氧环境下的心血管系统功能调节具有重要意义。
Objective:To investigate the changes of CNP (C-type natriuretic peptide)and ANP(atrial natriuretic peptide)in healthy youths inhabited in various altitude for different time.Methods:The serum CNP and ANP levels were examined by RIA(radioimmunoassay)among 40 health youths who arrived the elevations of 3 700 m and 5 380 m from 1 400 m after 7 day and 6 months ,and 20 health youths inhabited in plain were used as control. Results:The serum CNP and ANP levels in high altitude (3 700 m and 5 380 m for 7 days,5 380 m for 6 months)were significantly higher than those in plain group( P <0.05 or P <0.01).The ANP levels were significantly increased ( P <0.01) at 3 700 m for 6 months,but the CNP levels had no significance( P >0.05).Both CNP and ANP were significantly increased with the elevating of altitude ( P <0.05 or P <0.01) and the levels on the 7 th day were remarkably higher than those lived in high altitude for 6 months( P <0.05).Conclusion:The changes of serum CNP and ANP may play an important role in regulation of cardiovascular functions at high altitude
出处
《西北国防医学杂志》
CAS
2001年第1期27-28,共2页
Medical Journal of National Defending Forces in Northwest China
基金
国家自然科学基金资助项目! (3 970 191)
关键词
高原地区
C型利钠肽
心房利钠肽
缺氧
High altitude
C-type natriuretic peptide(CNP)
Atrial natriuretic peptide(ANP)
