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磺脲类药物受体基因多态性和2型糖尿病相关性研究 被引量：3

Study of relationship between sulfonylurea receptor gene polymorphism and type 2 diabetes
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摘要 目的 :调查糖尿病 (DM)患者磺脲类药物受体基因 16外显子 - 3T→C多态性与 2型DM相关性。　方法 :应用限制性内切酶片段长度多态性技术 ,对相互间无一级亲属关系的 15 5例 2型DM患者及 132名正常人中磺脲类药物受体基因第 16外显子 3T→C多态性进行遗传学相关性研究。　结果 :2型DM患者 16外显子 3T→C为“C”的等位基因及“CC”纯合子基因型频率比正常人显著增高 (P <0 .0 1)。　结论 :等位基因“C”所代表的单倍体在2型DM发病中遗传易感性上起重要作用。 Objective: To explore relationship between sulfonylurea receptor gene polymorphism and type 2 diabetes mellitus in Chinese subjects. Methods: Polymorphism of exon 16-3T→C in SUR gene 1 in 155 type 2 diabetic subjects and 132 controls were assessed by restriction fragment length polymorphism. Results: Frequency of “C” allele and “CC” homozygous phenotype in type 2 diabetic subjects was higher than that in control group. Conclusion:Allele “C” stands for hereditary susceptibility to diabetes.
作者 赵明 杜宏 王燕燕 王坚
机构地区 南京军区南京总医院内分泌科
出处 《医学研究生学报》 CAS 2004年第1期41-42,共2页 Journal of Medical Postgraduates
关键词 磺脲类药物受体 基因多态性 2型糖尿病 相关性 遗传易感性 Sulfonylurea receptor Diabetes mellitus Gene
分类号 R587.1 [医药卫生—内分泌] R962 [医药卫生—药理学]
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参考文献11

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二级参考文献11

  • 1刘皋林,陈强,李珍,沈意翔,李栋,陈解春,张根发.国产和进口格列齐特体外溶出度测定及其药物动力学特性比较[J].第二军医大学学报,1994,15(1):52-57. 被引量：5
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  • 8Prato SD,Kreutzenberg SVD,Ricco A,et al.Hepaticsensitivity to insulin: Effects of sulfonyurea drugs. The American Journal of The Medical Sciences . 1991
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  • 10B. Stirling,N. J. Cox,G. I. Bell,C. L. Hanis,R. S. Spielman,Dr. P. Concannon. Linkage studies in NIDDM with markers near the sulphonylurea receptor gene[J] 1995,Diabetologia(12):1479～1481

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二级引证文献12

医学研究生学报
2004年 第1期

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