摘要
为研究肺部感染对D 半乳糖(D gal)处理小鼠心脏的影响 ,选雄性NIH小鼠 36只以D gal处理(D gal组 )后分为肺感染 1天组、3天组及对照组。另有 36只小鼠以生理盐水处理 (NS组 )作为对照。D gal组感染鼠心肌线粒体损伤明显 ,丙二醛含量增加 ,SOD活性及ATP含量降低 ;心肌ATP含量与SOD活性呈正相关 (r=0 .5 1) ,与丙二醛含量呈负相关 (r=- 0 .43)。心肌中TNF α含量在D gal组与NS组无差别。结果提示 ,经D gal处理后心肌的脂质过氧化增加了肺感染时心肌的“易损性”。
To study the mechanism and influence of pneumonia on myocardium in D-galactose(D-gal) treated mice, 36 normal male NIH mice were randomly selected and pretreated with D-gal, and then they were divided into three groups, namely control group, the first day after pneumonia group, and the third day after pneumonia group. Another group of 36 mice were pretreated with normal saline to form a general control group. The result showed that in the D-gal prtreated pneumonia mice, the degeneration of myocardial mitochondria was more pronounced, the content of MDA in myocardium was increased, and the activity of SOD and the content of ATP in the myocardium were reduced. There was a positive correlation between the content of ATP and the activity of SOD, and there was a negative correlation between the content of ATP and MDA in the myocardium. These results suggusted that the myocardial lipid peroxidation in the D-gal treated mice increased the susceptibility to the damaging factors, such as pneumonia.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2003年第10期911-913,共3页
Medical Journal of Chinese People's Liberation Army
基金
国家重点基础研究发展规划基金资助课题 (编号G2 0 0 0 0 570 0 4 )
