摘要
目的 为探讨不同剂量CHO重组乙肝疫苗免疫效果及其联合HBIG阻断母婴传播的效果。 方法 采用血清流行病学的方法对CHO重组乙肝疫苗的免疫效果及联合HBIG阻断母婴传播效果进行追踪调查。 结果 乙肝疫苗不同免疫方案对HBsAg阴性产妇的新生儿产生抗 -HBs滴度 (GMT)的差异无显蓍的统计学意义 ;CHO重组乙肝疫苗2 0 μg -2 0 μg -2 0 μg组与其首针同时联合臀部肌肉注射HBIg 10 0IU组对产妇HBsAg、HBeAg单、双阳性的新生儿的母婴传播阻断率的差异有显著的统计学意义 (P <0 .0 5 )。 结论 CHO重组乙肝疫苗能产生较好的免疫效果 ,对HBsAg阴性产妇的新生儿采用CHO重组乙肝疫苗 2 0 μg -10 μg -10 μg进行免疫更为经济有效 ;CHO重组乙肝疫苗 2 0 μg -2 0μg -2 0 μg且首针同时联合臀部肌肉注射HBIg 10 0IU组阻断母婴乙肝传播效果优于单独使用CHO重组乙肝疫苗 2 0 μg-2 0 μg -2 0 μg组。
Objective To study the vaccination effect of different dose of CHO recombinated vaccine of hepatitis B(HB) and the effect of untied HBIG to block the vertical transmission of HB. Methods The sero-epidemiological method was used and follow-up study was carried out. Result No significant differences in the level of anti-HBs were found in the newborns vaccinated by different strategies delivered by puerperal with HBsAg negative. The effect of blocking vertical tranmission was significantly different between the newborns vaccinated by CHO recombinated vaccine (20 μg～20 μg～20 μg) and those injected by HBIg(100 IU) in the button at the first dose, no matter whose mothers were HBsAg positive, HBeAg positive or HBsAg and HBeAg all positive. Conclusion CHO recombinated hepatitis B vaccine had a good vaccination effect and it was more economical and effective to vaccinate the newborns by CHO recombinated vaccine(20 μg～10 μg～10 μg) delivered by puerperal with HBsAg negative. The effect of blocking vertical transmission by CHO recombinated vaccing(20 μg～20 μg～20 μg) and injected by HBIG(100 IU) in the buttock at the same time was superior to that by CHO recombinated vaccine(20 μg～20 μg～20 μg) individually.
出处
《实用预防医学》
CAS
2003年第6期842-845,共4页
Practical Preventive Medicine
基金
2 0 0 1年东莞市科学技术委员会科技计划
关键词
CHO重组乙肝疫苗
免疫效果
乙型肝炎母婴传播阻断率
CHO recombinated vaccine of hepatits B
Vaccination effect
Blocking rate of vertical transmission of hepatitis B
