摘要
目的 :利用频率比给各标志物评分 ,以总分的正负作为胸液良恶性的判定标准 ,旨在确定一种适合于临床应用的简单方法。方法 :选择经病理证实的良恶性胸液各 30例 ,用放射免疫分析法检测其CEA、CYFRA2 1 - 1、β2 - MG水平 ,应用频率比给各标记物评分 ,对联检结果进行良恶性的判定。结果 :三种标志物浓度在良恶性组中均有显著差别 (P<0 .0 0 1 ) ,其敏感度、特异度、准确度分别为 CEA(80 %、93.3%、86 .6 % ) ,CYFRA2 1 - 1 (80 %、86 .7%、83.3% ) ,β2 - MG(83.3%、83.3%、83.3% )。应用频率比对CEA、CYFRA2 1 - 1、β2 - MG联检的结果评分 ,以三者大于临界值时计分分别为 1 2 .0、6 .0、- 5 .0 ,小于临界值时计分为 - 4.0、- 4.3、+5 ,得回代敏感度 90 %、特异度 90 %、准确度 90 %。结论 :频率比评分是一种简单、有效的鉴别良恶性胸液方法 。
Objective:Tumor markers are used in clinic to differentiate benign and malignant pleural effusion for more than several decades. Combined determination is superior to individual, but judging method is so complex. The method frequency ratio grading was used to give every marker a fit mark and conclusion was gave based on its positive and negative result, so as to find a simple method to clinic. Methods: Radioimmunoassay was used to detect the levels of CEA、CYFRA21 1、β 2 MG of pleural effusion in 30 malignant and 30 benign pleural patients. Frequency ratio differentiating method was used to evaluate the combined result.Results: Significant differences of the three markers were found in benign and malignant pleural effusion(P<0.001).Sensitivity ,specificity and accuracy of the three tumor markers were as following:CEA(80%,93.3%,86.6%), CYFRA21 1 (80%, 86.7%,83.2%),β 2 MG(83.3%,83.3%,83.3%).The scores of three markers (CEA、CYFRA21 1、β 2 MG) being 12,6,-5 for higher than cut off points respectively and -4,-4.3,5,for lower by Frequency ratio grading. Its sensitivity、specificity and accuracy were all 90%。Conclusions: Our study showed that frequency ratio grading was simple and convenient in multi tumor markers differentiating benign and malignant pleural effusion and deserved to be popularized in clinic.
出处
《承德医学院学报》
2003年第4期279-282,共4页
Journal of Chengde Medical University
