摘要
目的 :探讨降钙素基因相关肽 (CGRP)对血管升压素 (AVP)缩血管效应的影响。方法 :培养大鼠主动脉血管平滑肌细胞 (VSMC) ,给予 AVP和 CGRP干预 ,检测 VSMC的细胞内游离钙离子浓度 ([Ca2 + ] i)。结果 :AVP增加VSMC的 [Ca2 + ] i,而 CGRP明显抑制 AVP的这一作用。结论 :CGRP可能通过抑制 VSMC的 [Ca2 + ] i的升高而发挥其对
AIM:To investigate the effect of calcitonin gene-related pe ptide(CGRP) on the vasoconstriction induced by arginine vasopressin(AVP). METHODS:The aortic vascular smooth muscle cell(VSMC) of rat was cultured to determine the cytosolic free Ca 2+ concentration ([Ca 2+ ] i) in the presence of CGRP and AVP. RESULTS:AVP increased [Ca 2+ ] i,which was signi ficant ly attenuated by CGRP. CONCLUSION:CGRP plays the inhibitory effect on AVP-induced vasoconstriction by confining increased [Ca 2+ ] i of VSMC.
出处
《心脏杂志》
CAS
2003年第6期493-494,共2页
Chinese Heart Journal
