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H^+、K^+-ATP酶的分子生物学研究进展及在药物研究中的应用 被引量:1

Progress of molecule biology aspects application in drug design of H^+ ,K^+-ATPase
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摘要 H+,K+-ATP酶抑制剂是胃及十二指肠溃疡的一类重要的治疗药物,我们曾对这类药物的研究进展做过综述[1].近年来,随着生物技术特别是分子生物学和生物信息学的发展,人们对H+,K+-ATP酶从分子水平的认识越来越清楚,特别是对药物和酶的作用位点的认识,必将推动H+,K+-ATP酶抑制剂有更新的发展.
出处 《中国药品标准》 CAS 2003年第6期5-8,共4页 Drug Standards of China
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  • 7Munson KB.Gutierrez C,Balaji VN,et al.Identification of an extracytoplasmic region of H+,K(+)--ATPase labeled by a K(+)-competitive photoaffinity inhibitor[].Journal of Biological Chemistry.1991
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  • 9Lingrel JB,Arguello JM,Van Huysse J. et al.Cation and cardiac glycoside binding sites of the Na, K-ATPase[].Annals of the New York Academy of Sciences.1997
  • 10Capasso JM,Hoving S,Tal DM. et al.Extensive digestion of Na~+, K~+-ATPase by specific and nonspecific proteases with preservation of cation occlusion sites[].Journal of Biological Chemistry.1992

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