摘要
目的 探讨舌癌不同浸润方式PCNA表达的差异及临床意义。方法 按Anneroth等介绍的方法将浸润方式分为4型。对32例舌癌原发灶进行SP免疫组化染色,观察其PCNA表达。结果 PCNA的表达与肿瘤浸润方式有关。Ⅲ、Ⅳ型浸润方式的舌癌癌细胞PCNA表达明显高于Ⅰ、Ⅱ型(P<0.01),且临床上易发生颈淋巴结转移及淋巴结包膜外侵犯。结论 浸润方式可作为临床判断舌癌恶性程度的有效指标之一,对舌癌的治疗有一定的意义。
Objective To investigate the clinical significance of PCNA expression in squamous cell carcinoma of the tongue with different pattern of invasion. Methods 32 consecutive cases with squamous cell carcinoma of the tongue were classified into four types according to the pattern of invasion and PCNA expression was detected respectively by using immu-nohistochemical staining. Results PCNA expression in the tumor cells varied from the pattern of invasion. The expression in the tongue cancer with pattern Ⅲ and Ⅳ of invasion had a higher level than that of pattern Ⅰ and Ⅱ. The difference was statistically significant (P < 0. 01). The clinical findings showed that the tongue cancer with pattern Ⅲ and Ⅳ of invasion were easily involved in metastatic diseases. Conclusion Pattern of invasion can be considered to be one of effective factors for evaluating the malignance grading of tongue cancer, which will be helpful to clinical treatment for tongue cancer.
出处
《口腔颌面外科杂志》
CAS
2003年第4期291-294,共4页
Journal of Oral and Maxillofacial Surgery
