摘要
目的 研究怀孕前父、母亲有不同浓度二硫化碳 (CS2 )接触史的儿童神经行为功能和尿中 5 羟吲哚乙酸(5 HIAA)改变。方法 选择怀孕前父亲或母亲有CS2 接触史者所生育的子女 61名为接触组 ,按父母接触水平分为高浓度组和低浓度组。同时选取同一地区父母无任何毒物接触史的 3 9名儿童为对照组 ,进行神经行为功能和尿中5 HIAA水平测试。结果 父亲或母亲接触高浓度组儿童注意力、反应速度、心理运动能力、运动协调能力都受到影响 ,低浓度组仅在视感知和运动协调能力方面有所影响。分成母亲接触组、父亲接触组与对照组比较 ,除心理运动能力外未见到其他指标测试结果的差异有显著性。尿中 5 HIAA水平 ,接触组与对照组儿童间差异未见有显著性。结论 接触CS2 对子代可产生一定的神经行为改变 ,且有一定的剂量
Objective To study effects of exposure to varied concentrations of carbon disulfide(CS 2)in workers on neurobehavior and urine level of 5 hydroxyindoleacetic acid(5 HIAA)in their children.Method Sixty one children,whose father or mother exposed to varied concentrations of CS 2 before their pregnancy,were selected.And,39 normal children,whose parents did not exposed to any kinds of toxicants,were selected from the same areas as controls.Neurobehavior and urine level of 5 HIAA were measured for all the children.Result Attention in children with their parents exposed to CS 2 slacked down,their reaction rate slowed,and their psychologic movement ability and motor concerted ability were affected,too.Only visual perception and motor concerted ability were affected in children with their parents exposed to low level of CS 2.There was no significant difference in all indicators,except for psychologic movement ability,between children with their mother exposed,their father exposed and controls.No significant difference in urine level of 5 HIAA was found between children with exposed parents and controls.Conclusion Exposure to CS 2 in parents could cause changes in neurobehavior of their children,to a certain extent,in a dose response
出处
《中国工业医学杂志》
CAS
北大核心
2003年第6期328-331,共4页
Chinese Journal of Industrial Medicine
