摘要
【目的】探讨有补肾活血、清热祛湿作用的中药制剂痛风康(由鹿角霜、川续断、牛膝、赤芍、毛冬青、威灵仙等组成)治疗急性痛风性关节炎的作用机理。【方法】以尿酸钠造成急性痛风性关节炎大鼠模型,观察痛风康对关节滑膜组织炎症病理变化的影响,同时设立正常组、模型组和西药别嘌呤醇组为对照。【结果】痛风康能显著缩小关节周径,改善痛行为步态;同时能减轻炎性细胞浸润,抑制纤维组织增生;且高剂量中药组优于西药组(P<0.05或P<0.01)。【结论】痛风康对急性痛风性关节炎有明显的抗炎镇痛、抗肿胀的作用。
【Objective】To explore the therapeutic mechanism of Tongfengkang in treating acute gouty arthritis (AGA) .
Tongfengkang is mainly composed of Colla Cornus Cervi, Radix Dipsaci, Radix Achyranthis Bidentatae, Radix Paeoniae
Rubra, Radix Ilicis Pubescentis and Radix Clematidis. 【Methods】The model of AGA was established by sodium urate.
Forty rats were randomized into five groups: Group A ( normal), B ( model) , C ( allopurinol) , D (low-dose
Tongfengkang) and E (high-dose Tongfengkang). Effects of Tongfengkang on inflammation in synovial tissues were
observed【Results】Tongfengkang could obviously lessen the perimeter of swollen joints, improve the pain gait,
decrease the infiltration of inflammatory cells and inhibit the proliferation of fibrous tissues; the effects of Group E was
better than those of Group C (P< 0.05 or P< 0.01). 【Conclusion】Tongfengkang has anti-inflammatory and analgesic
actions and can reduce joint swelling in acute gouty arthritis.
出处
《广州中医药大学学报》
CAS
2003年第4期285-288,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药管理局资助课题(编号:98321)
关键词
痛风康
急性痛风性关节炎
病理特点
作用机理
肿胀
动物模型
TONGFENGKANG/pharmacology
ARTHRITIS,GOUTY/TCD therapy
REINFORCING KINDNEY
ACTIVATING BLOOD
CLEAR HEAT DISSOLV DAMPNESS
DISEASE MODEIS,ANIMAL
