摘要
目的 探讨正电子发射体层显像 (PET)在诊断复发性卵巢恶性肿瘤中的价值。方法 选择行满意的肿瘤细胞减灭术 ,术后经 6～ 9个疗程的化学药物治疗 (化疗 ) ,临床完全缓解 6个月以上的 31例卵巢恶性肿瘤患者进行PET全身检查 35例次。在随访过程中同时进行PET和盆腹腔CT检查 2 2例次 ,通过二次探查术或再次肿瘤细胞减灭术并经病理学检查证实 ;13例次继续随访和结合多项检查进行评估 ,评价PET和CT在诊断复发性卵巢恶性肿瘤中的价值。结果 35例次PET检查中 ,1例透明细胞癌为假阴性 ,1例内胚窦瘤化疗后PET检查为假阳性 ,PET检查的灵敏度为 96 3% ,特异性为 87 5 % ;CT的灵敏度为 70 4 % ,特异性为 75 0 %。PET和CT的灵敏度比较 ,差异有显著性(P <0 0 5 )。结论 应用PET诊断复发性卵巢恶性肿瘤的效果优于CT ,可提高复发性卵巢恶性肿瘤的早期诊断。
Objective To investigate the efficiency of positron emission tomography ( PET) with(fluorine-18)-2-deoxyglucose( 18 FDG) in diagnosis of recurrent ovarian cancer. Methods 18 FDG-PET scanning and computerized tomography (CT) were performed on 31 patients 35 times, who were clinically free of disease after optimal cytoreductive surgery and first-line chemotherapy. Twenty-two patients were confirmed pathologically after second-look or re-debulking operation and the others were followed up by many methods (ultrasonography , CA 125 and pelvic examination combined), evaluating the role of PET and CT in the diagnosis of recurrent ovarian cancer. Results (1) PET demonstrated recurrent sites through increased 18 FDG uptake. In 35 times, PET showed 1 false-negative and 1 false-positive cases. (2) The sensitivity of 18 FDG-PET is 96.3%,and CT is 70.4%. There was significant difference between two groups ( P <0.05). Conclusion PET is more sensitive in diagnosing recurrent ovarian cancer than CT, so it improve early diagnosis in recurrent ovarian cancer.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2003年第11期667-669,共3页
Chinese Journal of Obstetrics and Gynecology
